| http://purl.uniprot.org/citations/26702057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26702057 | http://www.w3.org/2000/01/rdf-schema#comment | "Human chaperone DnaJB6, an Hsp70 co-chaperone whose defects cause myopathies, protects cells from polyglutamine toxicity and prevents purified polyglutamine and Aβ peptides from forming amyloid. Yeast prions [URE3] and [PSI(+)] propagate as amyloid forms of Ure2 and Sup35 proteins, respectively. Here we find DnaJB6-protected yeast cells from polyglutamine toxicity and cured yeast of both [URE3] prions and weak variants of [PSI(+)] prions but not strong [PSI(+)] prions. Weak and strong variants of [PSI(+)] differ only in the structural conformation of their amyloid cores. In line with its anti-prion effects, DnaJB6 prevented purified Sup35NM from forming amyloids at 37 °C, which produce predominantly weak [PSI(+)] variants when used to infect yeast, but not at 4 °C, which produces mostly strong [PSI(+)] variants. Thus, structurally distinct amyloids composed of the same protein were differentially sensitive to the anti-amyloid activity of DnaJB6 both in vitro and in vivo. These findings have important implications for strategies using DnaJB6 as a target for therapy in amyloid disorders."xsd:string |
| http://purl.uniprot.org/citations/26702057 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m115.700393"xsd:string |
| http://purl.uniprot.org/citations/26702057 | http://purl.uniprot.org/core/author | "Sharma R."xsd:string |
| http://purl.uniprot.org/citations/26702057 | http://purl.uniprot.org/core/author | "Masison D.C."xsd:string |
| http://purl.uniprot.org/citations/26702057 | http://purl.uniprot.org/core/author | "Roberts B.L."xsd:string |
| http://purl.uniprot.org/citations/26702057 | http://purl.uniprot.org/core/author | "Reidy M."xsd:string |
| http://purl.uniprot.org/citations/26702057 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26702057 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/26702057 | http://purl.uniprot.org/core/pages | "4035-4047"xsd:string |
| http://purl.uniprot.org/citations/26702057 | http://purl.uniprot.org/core/title | "Human J-protein DnaJB6b Cures a Subset of Saccharomyces cerevisiae Prions and Selectively Blocks Assembly of Structurally Related Amyloids."xsd:string |
| http://purl.uniprot.org/citations/26702057 | http://purl.uniprot.org/core/volume | "291"xsd:string |
| http://purl.uniprot.org/citations/26702057 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26702057 |
| http://purl.uniprot.org/citations/26702057 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26702057 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YX62-mappedCitation-26702057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26702057 |
| http://purl.uniprot.org/uniprot/#_A0A6A5Q8S5-mappedCitation-26702057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26702057 |
| http://purl.uniprot.org/uniprot/#_A7UJ17-mappedCitation-26702057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26702057 |
| http://purl.uniprot.org/uniprot/#_B4DMJ9-mappedCitation-26702057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26702057 |
| http://purl.uniprot.org/uniprot/#_B4DNN5-mappedCitation-26702057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26702057 |
| http://purl.uniprot.org/uniprot/#_B4DVN1-mappedCitation-26702057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26702057 |
| http://purl.uniprot.org/uniprot/#_H9BH29-mappedCitation-26702057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26702057 |
| http://purl.uniprot.org/uniprot/#_P23202-mappedCitation-26702057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26702057 |
| http://purl.uniprot.org/uniprot/#_O75190-mappedCitation-26702057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26702057 |
| http://purl.uniprot.org/uniprot/#_P05453-mappedCitation-26702057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26702057 |
| http://purl.uniprot.org/uniprot/#_Q49A72-mappedCitation-26702057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26702057 |