| http://purl.uniprot.org/citations/26702068 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26702068 | http://www.w3.org/2000/01/rdf-schema#comment | "Gene expression profiling has identified 2 major subclasses of diffuse large B-cell lymphoma (DLBCL). Cases resembling germinal center (GC) B cells (GCB-DLBCL) generally occur in younger patients, have a distinct molecular pathophysiology, and have improved outcomes compared with those similar to activated post-GC cells (activated B-cell DLBCL). We previously found that the ubiquitin hydrolase UCH-L1 is frequently overexpressed in mature B-cell malignancies and is a potent oncogene in mice. The cause for its overexpression in lymphoma, and whether it impacts the outcome of patients with DLBCL is unknown. Here, we show that UCH-L1 reflects GC lineage in lymphoma and is an oncogenic biomarker of aggressive GCB-DLBCL. We find that UCH-L1 is specifically induced in GC B cells in mice and humans, and that its expression correlates highly with the GCB subtype in DLBCL. We also find that UCH-L1 cooperates with BCL6 in a mouse model of GC B-cell lymphoma, but not with the development of multiple myeloma derived from post-GC cells. Despite the typically good outcomes of GCB-DLBCL, increased UCHL1 identifies a subgroup with early relapses independent of MYC expression, suggesting biological diversity in this subset of disease. Consistent with this, forced Uchl1 overexpression had a substantial impact on gene expression in GC B cells including pathways of cell cycle progression, cell death and proliferation, and DNA replication. These data demonstrate a novel role for UCH-L1 outside of the nervous system and suggest its potential use as a biomarker and therapeutic target in DLBCL."xsd:string |
| http://purl.uniprot.org/citations/26702068 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2015-07-656678"xsd:string |
| http://purl.uniprot.org/citations/26702068 | http://purl.uniprot.org/core/author | "Hussain S."xsd:string |
| http://purl.uniprot.org/citations/26702068 | http://purl.uniprot.org/core/author | "Bedekovics T."xsd:string |
| http://purl.uniprot.org/citations/26702068 | http://purl.uniprot.org/core/author | "Galardy P.J."xsd:string |
| http://purl.uniprot.org/citations/26702068 | http://purl.uniprot.org/core/author | "Feldman A.L."xsd:string |
| http://purl.uniprot.org/citations/26702068 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26702068 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/26702068 | http://purl.uniprot.org/core/pages | "1564-1574"xsd:string |
| http://purl.uniprot.org/citations/26702068 | http://purl.uniprot.org/core/title | "UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma."xsd:string |
| http://purl.uniprot.org/citations/26702068 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/26702068 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26702068 |
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