| http://purl.uniprot.org/citations/26706316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26706316 | http://www.w3.org/2000/01/rdf-schema#comment | "Phospholipase C-related catalytically inactive protein (PRIP) was first identified as an inositol 1,4,5-trisphosphate-binding protein, and was later found to be involved in a variety of cellular events, particularly those related to protein phosphatases. We previously reported that Prip knock-out (KO) mice exhibit a lean phenotype with a small amount of white adipose tissue. In the present study, we examined whether PRIP is involved in energy metabolism, which could explain the lean phenotype, using high-fat diet (HFD)-fed mice. Prip-KO mice showed resistance to HFD-induced obesity, resulting in protection from glucose metabolism dysfunction and insulin resistance. Energy expenditure and body temperature at night were significantly higher in Prip-KO mice than in wild-type mice. Gene and protein expression of uncoupling protein 1 (UCP1), a thermogenic protein, was up-regulated in Prip-KO brown adipocytes in thermoneutral or cold environments. These phenotypes were caused by the promotion of lipolysis in Prip-KO brown adipocytes, which is triggered by up-regulation of phosphorylation of the lipolysis-related proteins hormone-sensitive lipase and perilipin, followed by activation of UCP1 and/or up-regulation of thermogenesis-related genes (e.g. peroxisome proliferator-activated receptor-γ coactivator-1α). The results indicate that PRIP negatively regulates UCP1-mediated thermogenesis in brown adipocytes."xsd:string |
| http://purl.uniprot.org/citations/26706316 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m115.705723"xsd:string |
| http://purl.uniprot.org/citations/26706316 | http://purl.uniprot.org/core/author | "Hirata M."xsd:string |
| http://purl.uniprot.org/citations/26706316 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/26706316 | http://purl.uniprot.org/core/author | "Takata T."xsd:string |
| http://purl.uniprot.org/citations/26706316 | http://purl.uniprot.org/core/author | "Asano S."xsd:string |
| http://purl.uniprot.org/citations/26706316 | http://purl.uniprot.org/core/author | "Kanematsu T."xsd:string |
| http://purl.uniprot.org/citations/26706316 | http://purl.uniprot.org/core/author | "Hayashiuchi M."xsd:string |
| http://purl.uniprot.org/citations/26706316 | http://purl.uniprot.org/core/author | "Irifune M."xsd:string |
| http://purl.uniprot.org/citations/26706316 | http://purl.uniprot.org/core/author | "Oue K."xsd:string |
| http://purl.uniprot.org/citations/26706316 | http://purl.uniprot.org/core/author | "Yamawaki Y."xsd:string |
| http://purl.uniprot.org/citations/26706316 | http://purl.uniprot.org/core/author | "Furusho H."xsd:string |
| http://purl.uniprot.org/citations/26706316 | http://purl.uniprot.org/core/author | "Harada-Hada K."xsd:string |
| http://purl.uniprot.org/citations/26706316 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26706316 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/26706316 | http://purl.uniprot.org/core/pages | "4185-4196"xsd:string |
| http://purl.uniprot.org/citations/26706316 | http://purl.uniprot.org/core/title | "Phospholipase C-related Catalytically Inactive Protein Is a New Modulator of Thermogenesis Promoted by beta-Adrenergic Receptors in Brown Adipocytes."xsd:string |
| http://purl.uniprot.org/citations/26706316 | http://purl.uniprot.org/core/volume | "291"xsd:string |
| http://purl.uniprot.org/citations/26706316 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26706316 |
| http://purl.uniprot.org/citations/26706316 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26706316 |
| http://purl.uniprot.org/uniprot/Q8K394#attribution-5783661670C3A67B81AF34D45B9C4BF2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26706316 |
| http://purl.uniprot.org/uniprot/Q62688#attribution-E22A2BAB21B4506E8BF32FECADE6F5FE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26706316 |
| http://purl.uniprot.org/uniprot/Q15111#attribution-E22A2BAB21B4506E8BF32FECADE6F5FE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26706316 |
| http://purl.uniprot.org/uniprot/Q9UPR0#attribution-E22A2BAB21B4506E8BF32FECADE6F5FE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/26706316 |