| http://purl.uniprot.org/citations/26710261 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26710261 | http://www.w3.org/2000/01/rdf-schema#comment | "The initiation of DNA replication is a highly regulated event in eukaryotic cells to ensure that the entire genome is copied once and only once during S phase. The primary target of cellular regulation of eukaryotic DNA replication initiation is the assembly and activation of the replication fork helicase, the 11-subunit assembly that unwinds DNA at a replication fork. The replication fork helicase, called CMG for Cdc45-Mcm2-7, and GINS, assembles in S phase from the constituent Cdc45, Mcm2-7, and GINS proteins. The assembly and activation of the CMG replication fork helicase during S phase is governed by 2 S-phase specific kinases, CDK and DDK. CDK stimulates the interaction between Sld2, Sld3, and Dpb11, 3 initiation factors that are each required for the initiation of DNA replication. DDK, on the other hand, phosphorylates the Mcm2, Mcm4, and Mcm6 subunits of the Mcm2-7 complex. Sld3 recruits Cdc45 to Mcm2-7 in a manner that depends on DDK, and recent work suggests that Sld3 binds directly to Mcm2-7 and also to single-stranded DNA. Furthermore, recent work demonstrates that Sld3 and its human homolog Treslin substantially stimulate DDK phosphorylation of Mcm2. These data suggest that the initiation factor Sld3/Treslin coordinates the assembly and activation of the eukaryotic replication fork helicase by recruiting Cdc45 to Mcm2-7, stimulating DDK phosphorylation of Mcm2, and binding directly to single-stranded DNA as the origin is melted."xsd:string |
| http://purl.uniprot.org/citations/26710261 | http://purl.org/dc/terms/identifier | "doi:10.1080/19491034.2015.1115938"xsd:string |
| http://purl.uniprot.org/citations/26710261 | http://purl.uniprot.org/core/author | "Perez-Arnaiz P."xsd:string |
| http://purl.uniprot.org/citations/26710261 | http://purl.uniprot.org/core/author | "Kaplan D.L."xsd:string |
| http://purl.uniprot.org/citations/26710261 | http://purl.uniprot.org/core/author | "Bruck I."xsd:string |
| http://purl.uniprot.org/citations/26710261 | http://purl.uniprot.org/core/author | "Colbert M.K."xsd:string |
| http://purl.uniprot.org/citations/26710261 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26710261 | http://purl.uniprot.org/core/name | "Nucleus"xsd:string |
| http://purl.uniprot.org/citations/26710261 | http://purl.uniprot.org/core/pages | "449-454"xsd:string |
| http://purl.uniprot.org/citations/26710261 | http://purl.uniprot.org/core/title | "Insights into the Initiation of Eukaryotic DNA Replication."xsd:string |
| http://purl.uniprot.org/citations/26710261 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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