| http://purl.uniprot.org/citations/26713365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26713365 | http://www.w3.org/2000/01/rdf-schema#comment | "To explore possible roles of heparanase in cancer-host crosstalk, we examined whether heparanase influences expression of inflammatory chemokines in colorectal cancer cells. Murine colorectal carcinoma cells incubated with heparanase upregulated MCP-1, KC, and RANTES genes and released MCP-1 and KC proteins. Heparanase-dependent production of IL-8 was detected in two human colorectal carcinoma cell lines. Addition of a heparanase inhibitor Heparastatin (SF4) did not influence MCP-1 production, while both latent and mature forms of heparanase augmented MCP-1 release, suggesting that heparanase catalytic activity was dispensable for MCP-1 production. In contrast, addition of heparin to the medium suppressed MCP-1 release in a dose-dependent manner. Similarly, targeted suppression of Ext1 by RNAi significantly suppressed cell surface expression of heparan sulfate and MCP-1 production in colon 26 cells. Taken together, it is concluded that colon 26 cells transduce the heparanase-mediated signal through heparan sulfate binding. We propose a novel function for heparanase independent of its endoglycosidase activity, namely as a stimulant for chemokine production."xsd:string |
| http://purl.uniprot.org/citations/26713365 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2015.12.074"xsd:string |
| http://purl.uniprot.org/citations/26713365 | http://purl.uniprot.org/core/author | "Nishimura Y."xsd:string |
| http://purl.uniprot.org/citations/26713365 | http://purl.uniprot.org/core/author | "Nakajima M."xsd:string |
| http://purl.uniprot.org/citations/26713365 | http://purl.uniprot.org/core/author | "Shida H."xsd:string |
| http://purl.uniprot.org/citations/26713365 | http://purl.uniprot.org/core/author | "Adachi H."xsd:string |
| http://purl.uniprot.org/citations/26713365 | http://purl.uniprot.org/core/author | "Higashi N."xsd:string |
| http://purl.uniprot.org/citations/26713365 | http://purl.uniprot.org/core/author | "Irimura T."xsd:string |
| http://purl.uniprot.org/citations/26713365 | http://purl.uniprot.org/core/author | "Waki M."xsd:string |
| http://purl.uniprot.org/citations/26713365 | http://purl.uniprot.org/core/author | "Tsunekawa N."xsd:string |
| http://purl.uniprot.org/citations/26713365 | http://purl.uniprot.org/core/author | "Kogane Y."xsd:string |
| http://purl.uniprot.org/citations/26713365 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26713365 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/26713365 | http://purl.uniprot.org/core/pages | "878-883"xsd:string |
| http://purl.uniprot.org/citations/26713365 | http://purl.uniprot.org/core/title | "Heparanase augments inflammatory chemokine production from colorectal carcinoma cell lines."xsd:string |
| http://purl.uniprot.org/citations/26713365 | http://purl.uniprot.org/core/volume | "469"xsd:string |
| http://purl.uniprot.org/citations/26713365 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26713365 |
| http://purl.uniprot.org/citations/26713365 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26713365 |
| http://purl.uniprot.org/uniprot/#_E9PFG6-mappedCitation-26713365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26713365 |
| http://purl.uniprot.org/uniprot/#_B3KQR6-mappedCitation-26713365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26713365 |
| http://purl.uniprot.org/uniprot/#_D9IUY7-mappedCitation-26713365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26713365 |
| http://purl.uniprot.org/uniprot/#_Q9Y251-mappedCitation-26713365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26713365 |
| http://purl.uniprot.org/uniprot/Q9Y251 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26713365 |
| http://purl.uniprot.org/uniprot/B3KQR6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26713365 |