RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/26717478http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26717478http://www.w3.org/2000/01/rdf-schema#comment"Processes taking place in the secretory organelles require Ca2+ and Mn2+, which in yeast are supplied by the Pmr1 ion pump. Here we observed that in the yeast Hansenula polymorpha Ca2+ deficiency in the secretory pathway caused by Pmr1 inactivation is exacerbated by (i) the ret1-27 mutation affecting COPI-mediated vesicular transport, (ii) inactivation of the vacuolar Ca2+ ATPase Pmc1 and (iii) inactivation of Vps35, which is a component of the retromer complex responsible for protein transport between the vacuole and secretory organelles. The ret1-27 mutation also exerted phenotypes indicating alterations in transport between the vacuole and secretory organelles. These data indicate that ret1-27, pmc1 and vps35 affect a previously unknown Pmr1-independent route of the Ca2+ delivery to the secretory pathway. We also observed that the vacuolar protein carboxypeptidase Y receives additional modifications of its glycoside chains if it escapes the Vps10-dependent sorting to the vacuole."xsd:string
http://purl.uniprot.org/citations/26717478http://purl.org/dc/terms/identifier"doi:10.1371/journal.pone.0145915"xsd:string
http://purl.uniprot.org/citations/26717478http://purl.uniprot.org/core/author"Agaphonov M.O."xsd:string
http://purl.uniprot.org/citations/26717478http://purl.uniprot.org/core/author"Ter-Avanesyan M.D."xsd:string
http://purl.uniprot.org/citations/26717478http://purl.uniprot.org/core/author"Chechenova M.B."xsd:string
http://purl.uniprot.org/citations/26717478http://purl.uniprot.org/core/author"Fokina A.V."xsd:string
http://purl.uniprot.org/citations/26717478http://purl.uniprot.org/core/author"Karginov A.V."xsd:string
http://purl.uniprot.org/citations/26717478http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/26717478http://purl.uniprot.org/core/name"PLoS One"xsd:string
http://purl.uniprot.org/citations/26717478http://purl.uniprot.org/core/pages"e0145915"xsd:string
http://purl.uniprot.org/citations/26717478http://purl.uniprot.org/core/title"Genetic Evidence for the Role of the Vacuole in Supplying Secretory Organelles with Ca2+ in Hansenula polymorpha."xsd:string
http://purl.uniprot.org/citations/26717478http://purl.uniprot.org/core/volume"10"xsd:string
http://purl.uniprot.org/citations/26717478http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26717478
http://purl.uniprot.org/citations/26717478http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26717478
http://purl.uniprot.org/uniprot/#_P13586-mappedCitation-26717478http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26717478
http://purl.uniprot.org/uniprot/#_P34110-mappedCitation-26717478http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26717478
http://purl.uniprot.org/uniprot/#_P38929-mappedCitation-26717478http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26717478
http://purl.uniprot.org/uniprot/P34110http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/26717478
http://purl.uniprot.org/uniprot/P13586http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/26717478
http://purl.uniprot.org/uniprot/P38929http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/26717478