| http://purl.uniprot.org/citations/26719333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26719333 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibroblast growth factor (FGF) signaling regulates a multitude of cellular processes, including cell proliferation, survival, migration, and differentiation. In the vertebrate lens, FGF signaling regulates fiber cell differentiation characterized by high expression of crystallin proteins. However, a direct link between FGF signaling and crystallin gene transcriptional machinery remains to be established. Previously, we have shown that the bZIP proto-oncogene c-Maf regulates expression of αA-crystallin (Cryaa) through binding to its promoter and distal enhancer, DCR1, both activated by FGF2 in cell culture. Herein, we identified and characterized a novel FGF2-responsive region in the c-Maf promoter (-272/-70, FRE). Both c-Maf and Cryaa regulatory regions contain arrays of AP-1 and Ets-binding sites. Chromatin immunoprecipitation (ChIP) assays established binding of c-Jun (an AP-1 factor) and Etv5/ERM (an Ets factor) to these regions in lens chromatin. Analysis of temporal and spatial expression of c-Jun, phospho-c-Jun, and Etv5/ERM in wild type and ERK1/2 deficient lenses supports their roles as nuclear effectors of FGF signaling in mouse embryonic lens. Collectively, these studies show that FGF signaling up-regulates expression of αA-crystallin both directly and indirectly via up-regulation of c-Maf. These molecular mechanisms are applicable for other crystallins and genes highly expressed in terminally differentiated lens fibers."xsd:string |
| http://purl.uniprot.org/citations/26719333 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m115.705103"xsd:string |
| http://purl.uniprot.org/citations/26719333 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/26719333 | http://purl.uniprot.org/core/author | "Xie Q."xsd:string |
| http://purl.uniprot.org/citations/26719333 | http://purl.uniprot.org/core/author | "Harris R."xsd:string |
| http://purl.uniprot.org/citations/26719333 | http://purl.uniprot.org/core/author | "Gao C.Y."xsd:string |
| http://purl.uniprot.org/citations/26719333 | http://purl.uniprot.org/core/author | "Musil L.S."xsd:string |
| http://purl.uniprot.org/citations/26719333 | http://purl.uniprot.org/core/author | "Cvekl A."xsd:string |
| http://purl.uniprot.org/citations/26719333 | http://purl.uniprot.org/core/author | "Reneker L.W."xsd:string |
| http://purl.uniprot.org/citations/26719333 | http://purl.uniprot.org/core/author | "McGreal R."xsd:string |
| http://purl.uniprot.org/citations/26719333 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26719333 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/26719333 | http://purl.uniprot.org/core/pages | "3947-3958"xsd:string |
| http://purl.uniprot.org/citations/26719333 | http://purl.uniprot.org/core/title | "Regulation of c-Maf and alphaA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling."xsd:string |
| http://purl.uniprot.org/citations/26719333 | http://purl.uniprot.org/core/volume | "291"xsd:string |
| http://purl.uniprot.org/citations/26719333 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26719333 |
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