| http://purl.uniprot.org/citations/26724472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26724472 | http://www.w3.org/2000/01/rdf-schema#comment | "MMNG HOS Transforming gene (MET) is an important driver gene in non-small cell lung cancer. Yet, MET-relevant biomarkers predictive of clinical response to MET inhibitors remain elusive. Limited studies have indicated some possibly effective biomarkers, including amplification with a high-level MET/centromere probe of chromosome 7 (CEP7) ratio, MET exon 14 (METex14) splicing mutations, and MET overexpression. MET copy number gain (MCNG) is an independent negative prognostic factor in non-small cell lung cancer. Therefore, there remains a lack of clinical evidence regarding whether MCNG is a biomarker predictive of response to MET inhibitors. Here we report a patient with lung adenocarcinoma with MCNG but without a high-level MET/CEP7 ratio or METex14 splicing mutations who achieved a rapid response to crizotinib, indicating that MCNG may be an independent predictive biomarker for response to MET inhibitors."xsd:string |
| http://purl.uniprot.org/citations/26724472 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jtho.2015.12.102"xsd:string |
| http://purl.uniprot.org/citations/26724472 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/26724472 | http://purl.uniprot.org/core/author | "Tian Y."xsd:string |
| http://purl.uniprot.org/citations/26724472 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/26724472 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/26724472 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/26724472 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/26724472 | http://purl.uniprot.org/core/author | "Huang M."xsd:string |
| http://purl.uniprot.org/citations/26724472 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26724472 | http://purl.uniprot.org/core/name | "J Thorac Oncol"xsd:string |
| http://purl.uniprot.org/citations/26724472 | http://purl.uniprot.org/core/pages | "e59-e62"xsd:string |
| http://purl.uniprot.org/citations/26724472 | http://purl.uniprot.org/core/title | "Response to Crizotinib Observed in Lung Adenocarcinoma with MET Copy Number Gain but without a High-Level MET/CEP7 Ratio, MET Overexpression, or Exon 14 Splicing Mutations."xsd:string |
| http://purl.uniprot.org/citations/26724472 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/26724472 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26724472 |
| http://purl.uniprot.org/citations/26724472 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26724472 |
| http://purl.uniprot.org/uniprot/#_A5D6Q9-mappedCitation-26724472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26724472 |
| http://purl.uniprot.org/uniprot/#_B5A935-mappedCitation-26724472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26724472 |
| http://purl.uniprot.org/uniprot/#_B5A936-mappedCitation-26724472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26724472 |
| http://purl.uniprot.org/uniprot/#_B5A937-mappedCitation-26724472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26724472 |
| http://purl.uniprot.org/uniprot/#_B5A938-mappedCitation-26724472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26724472 |
| http://purl.uniprot.org/uniprot/#_B5A939-mappedCitation-26724472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26724472 |
| http://purl.uniprot.org/uniprot/#_B5A940-mappedCitation-26724472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26724472 |
| http://purl.uniprot.org/uniprot/#_B5A941-mappedCitation-26724472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26724472 |