| http://purl.uniprot.org/citations/26728651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26728651 | http://www.w3.org/2000/01/rdf-schema#comment | "Antigen receptor diversity underpins adaptive immunity by providing the ground for clonal selection of lymphocytes with the appropriate antigen reactivity. Current models attribute T cell clonal selection during the immune response to T-cell receptor (TCR) affinity for either foreign or self peptides. Here, we report that clonal selection of CD4(+) T cells is also extrinsically regulated by B cells. In response to viral infection, the antigen-specific TCR repertoire is progressively diversified by staggered clonotypic expansion, according to functional avidity, which correlates with self-reactivity. Clonal expansion of lower-avidity T-cell clonotypes depends on availability of MHC II-expressing B cells, in turn influenced by B-cell activation. B cells clonotypically diversify the CD4(+) T-cell response also to vaccination or tumour challenge, revealing a common effect."xsd:string |
| http://purl.uniprot.org/citations/26728651 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms10281"xsd:string |
| http://purl.uniprot.org/citations/26728651 | http://purl.uniprot.org/core/author | "Kassiotis G."xsd:string |
| http://purl.uniprot.org/citations/26728651 | http://purl.uniprot.org/core/author | "Pepper M."xsd:string |
| http://purl.uniprot.org/citations/26728651 | http://purl.uniprot.org/core/author | "Filby A."xsd:string |
| http://purl.uniprot.org/citations/26728651 | http://purl.uniprot.org/core/author | "Ploquin M.J."xsd:string |
| http://purl.uniprot.org/citations/26728651 | http://purl.uniprot.org/core/author | "Merkenschlager J."xsd:string |
| http://purl.uniprot.org/citations/26728651 | http://purl.uniprot.org/core/author | "Eksmond U."xsd:string |
| http://purl.uniprot.org/citations/26728651 | http://purl.uniprot.org/core/author | "Andargachew R."xsd:string |
| http://purl.uniprot.org/citations/26728651 | http://purl.uniprot.org/core/author | "Thorborn G."xsd:string |
| http://purl.uniprot.org/citations/26728651 | http://purl.uniprot.org/core/author | "Evavold B."xsd:string |
| http://purl.uniprot.org/citations/26728651 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26728651 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/26728651 | http://purl.uniprot.org/core/pages | "10281"xsd:string |
| http://purl.uniprot.org/citations/26728651 | http://purl.uniprot.org/core/title | "Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response."xsd:string |
| http://purl.uniprot.org/citations/26728651 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/26728651 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26728651 |
| http://purl.uniprot.org/citations/26728651 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26728651 |
| http://purl.uniprot.org/uniprot/#_A0A075B5P6-mappedCitation-26728651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26728651 |
| http://purl.uniprot.org/uniprot/#_A0A075B6A0-mappedCitation-26728651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26728651 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-26728651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26728651 |
| http://purl.uniprot.org/uniprot/#_D3YXL4-mappedCitation-26728651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26728651 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-26728651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26728651 |
| http://purl.uniprot.org/uniprot/#_A0A494B9U2-mappedCitation-26728651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26728651 |