| http://purl.uniprot.org/citations/26728854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26728854 | http://www.w3.org/2000/01/rdf-schema#comment | "Lipid droplets (LDs) in the nucleus of hepatocyte-derived cell lines were found to be associated with premyelocytic leukemia (PML) nuclear bodies (NBs) and type I nucleoplasmic reticulum (NR) or the extension of the inner nuclear membrane. Knockdown of PML isoform II (PML-II) caused a significant decrease in both nuclear LDs and type I NR, whereas overexpression of PML-II increased both. Notably, these effects were evident only in limited types of cells, in which a moderate number of nuclear LDs exist intrinsically, and PML-II was targeted not only at PML NBs, but also at the nuclear envelope, excluding lamins and SUN proteins. Knockdown of SUN proteins induced a significant increase in the type I NR and nuclear LDs, but these effects were cancelled by simultaneous knockdown of PML-II. Nuclear LDs harbored diacylglycerol O-acyltransferase 2 and CTP:phosphocholine cytidylyltransferase α and incorporated newly synthesized lipid esters. These results corroborated that PML-II plays a critical role in generating nuclear LDs in specific cell types."xsd:string |
| http://purl.uniprot.org/citations/26728854 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201507122"xsd:string |
| http://purl.uniprot.org/citations/26728854 | http://purl.uniprot.org/core/author | "Cheng J."xsd:string |
| http://purl.uniprot.org/citations/26728854 | http://purl.uniprot.org/core/author | "Jokitalo E."xsd:string |
| http://purl.uniprot.org/citations/26728854 | http://purl.uniprot.org/core/author | "Kawai T."xsd:string |
| http://purl.uniprot.org/citations/26728854 | http://purl.uniprot.org/core/author | "Yoshikawa Y."xsd:string |
| http://purl.uniprot.org/citations/26728854 | http://purl.uniprot.org/core/author | "Fujimoto T."xsd:string |
| http://purl.uniprot.org/citations/26728854 | http://purl.uniprot.org/core/author | "Ohsaki Y."xsd:string |
| http://purl.uniprot.org/citations/26728854 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26728854 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/26728854 | http://purl.uniprot.org/core/pages | "29-38"xsd:string |
| http://purl.uniprot.org/citations/26728854 | http://purl.uniprot.org/core/title | "PML isoform II plays a critical role in nuclear lipid droplet formation."xsd:string |
| http://purl.uniprot.org/citations/26728854 | http://purl.uniprot.org/core/volume | "212"xsd:string |
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