| http://purl.uniprot.org/citations/26728997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26728997 | http://www.w3.org/2000/01/rdf-schema#comment | "Soluble fms-like tyrosine kinase-1 (sFlt-1) functions as a potent inhibitor of angiogenesis by trapping vascular endothelial growth factor (VEGF). However, the precise regulatory mechanism of sFlt-1 production is unknown. Here, we report that vascular sFlt-1 production is regulated by heterogeneous nuclear ribonucleoprotein D (hnRNP D) and arginine methylation. We showed that hnRNP D bound to Flt-1 pre-mRNA and that hnRNP D overexpression decreased sFlt-1 mRNA in human microvascular endothelial cells (HMVECs). In contrast, the reduction of hnRNP D levels induced an increase in sFlt-1 production. Overexpression of an hnRNP D mutant in which the arginine residue of the known arginine methylation motif (arginine-glycine-glycine; RGG) was replaced with alanine did not reduce the level of soluble-form RNA produced from the Flt-1 minigene. Moreover, we demonstrated that overexpression of arginine methyltransferase decreased the soluble-form RNA level, whereas overexpression of arginine demethylase and addition of methyltransferase inhibitors increased sFlt-1 mRNA levels. These findings indicate that hnRNP D and arginine methylation play important roles in the regulation of Flt-1 mRNA alternative polyadenylation."xsd:string |
| http://purl.uniprot.org/citations/26728997 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11010-015-2649-y"xsd:string |
| http://purl.uniprot.org/citations/26728997 | http://purl.uniprot.org/core/author | "Ikeda T."xsd:string |
| http://purl.uniprot.org/citations/26728997 | http://purl.uniprot.org/core/author | "Saito H."xsd:string |
| http://purl.uniprot.org/citations/26728997 | http://purl.uniprot.org/core/author | "Yonekura H."xsd:string |
| http://purl.uniprot.org/citations/26728997 | http://purl.uniprot.org/core/author | "Yoshitake Y."xsd:string |
| http://purl.uniprot.org/citations/26728997 | http://purl.uniprot.org/core/author | "Ishigaki Y."xsd:string |
| http://purl.uniprot.org/citations/26728997 | http://purl.uniprot.org/core/author | "Shimasaki T."xsd:string |
| http://purl.uniprot.org/citations/26728997 | http://purl.uniprot.org/core/author | "Kobata T."xsd:string |
| http://purl.uniprot.org/citations/26728997 | http://purl.uniprot.org/core/author | "Yoshitomi Y."xsd:string |
| http://purl.uniprot.org/citations/26728997 | http://purl.uniprot.org/core/author | "Tomosugi N."xsd:string |
| http://purl.uniprot.org/citations/26728997 | http://purl.uniprot.org/core/author | "Yamaya H."xsd:string |
| http://purl.uniprot.org/citations/26728997 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26728997 | http://purl.uniprot.org/core/name | "Mol Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/26728997 | http://purl.uniprot.org/core/pages | "155-164"xsd:string |
| http://purl.uniprot.org/citations/26728997 | http://purl.uniprot.org/core/title | "Regulation of soluble Flt-1 (VEGFR-1) production by hnRNP D and protein arginine methylation."xsd:string |
| http://purl.uniprot.org/citations/26728997 | http://purl.uniprot.org/core/volume | "413"xsd:string |
| http://purl.uniprot.org/citations/26728997 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26728997 |
| http://purl.uniprot.org/citations/26728997 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26728997 |
| http://purl.uniprot.org/uniprot/#_H9N1E7-mappedCitation-26728997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26728997 |
| http://purl.uniprot.org/uniprot/#_H9N1E8-mappedCitation-26728997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26728997 |
| http://purl.uniprot.org/uniprot/#_B4DTC3-mappedCitation-26728997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26728997 |
| http://purl.uniprot.org/uniprot/#_B5A924-mappedCitation-26728997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26728997 |
| http://purl.uniprot.org/uniprot/#_B1AC84-mappedCitation-26728997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26728997 |