| http://purl.uniprot.org/citations/26739451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26739451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26739451 | http://www.w3.org/2000/01/rdf-schema#comment | "SWI/SNF ATP-dependent chromatin-remodeling complexes have been related to several cellular processes such as transcription, regulation of chromosomal stability, and DNA repair. The Caenorhabditis elegans gene ham-3 (also known as swsn-2.1) and its paralog swsn-2.2 encode accessory subunits of SWI/SNF complexes. Using RNA interference (RNAi) assays and diverse alleles we investigated whether ham-3 and swsn-2.2 have different functions during C. elegans development since they encode proteins that are probably mutually exclusive in a given SWI/SNF complex. We found that ham-3 and swsn-2.2 display similar functions in vulva specification, germline development, and intestinal cell proliferation, but have distinct roles in embryonic development. Accordingly, we detected functional redundancy in some developmental processes and demonstrated by RNA sequencing of RNAi-treated L4 animals that ham-3 and swsn-2.2 regulate the expression of a common subset of genes but also have specific targets. Cell lineage analyses in the embryo revealed hyper-proliferation of intestinal cells in ham-3 null mutants whereas swsn-2.2 is required for proper cell divisions. Using a proteomic approach, we identified SWSN-2.2-interacting proteins needed for early cell divisions, such as SAO-1 and ATX-2, and also nuclear envelope proteins such as MEL-28. swsn-2.2 mutants phenocopy mel-28 loss-of-function, and we observed that SWSN-2.2 and MEL-28 colocalize in mitotic and meiotic chromosomes. Moreover, we demonstrated that SWSN-2.2 is required for correct chromosome segregation and nuclear reassembly after mitosis including recruitment of MEL-28 to the nuclear periphery."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.115.183533"xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.115.183533"xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Ayuso C."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Ayuso C."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Askjaer P."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Askjaer P."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Ceron J."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Ceron J."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Porta-de-la-Riva M."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Porta-de-la-Riva M."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Cabello J."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Cabello J."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Aristizabal-Corrales D."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Aristizabal-Corrales D."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Rubio-Pena K."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Rubio-Pena K."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Ertl I."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Ertl I."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Fontrodona L."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Fontrodona L."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Cornes E."xsd:string |
| http://purl.uniprot.org/citations/26739451 | http://purl.uniprot.org/core/author | "Cornes E."xsd:string |