| http://purl.uniprot.org/citations/26740045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26740045 | http://www.w3.org/2000/01/rdf-schema#comment | "The nucleoporin Nup98 is frequently rearranged to form leukemogenic Nup98-fusion proteins with various partners. However, their function remains largely elusive. Here, we show that Nup98-HoxA9, a fusion between Nup98 and the homeobox transcription factor HoxA9, forms nuclear aggregates that frequently associate with facultative heterochromatin. We demonstrate that stable expression of Nup98-HoxA9 in mouse embryonic stem cells selectively induces the expression of Hox cluster genes. Genome-wide binding site analysis revealed that Nup98-HoxA9 is preferentially targeted and accumulated at Hox cluster regions where the export factor Crm1 is originally prebound. In addition, leptomycin B, an inhibitor of Crm1, disassembled nuclear Nup98-HoxA9 dots, resulting in the loss of chromatin binding of Nup98-HoxA9 and Nup98-HoxA9-mediated activation of Hox genes. Collectively, our results indicate that highly selective targeting of Nup98-fusion proteins to Hox cluster regions via prebound Crm1 induces the formation of higher order chromatin structures that causes aberrant Hox gene regulation."xsd:string |
| http://purl.uniprot.org/citations/26740045 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.09540"xsd:string |
| http://purl.uniprot.org/citations/26740045 | http://purl.uniprot.org/core/author | "Oka M."xsd:string |
| http://purl.uniprot.org/citations/26740045 | http://purl.uniprot.org/core/author | "Kimura H."xsd:string |
| http://purl.uniprot.org/citations/26740045 | http://purl.uniprot.org/core/author | "Yamada K."xsd:string |
| http://purl.uniprot.org/citations/26740045 | http://purl.uniprot.org/core/author | "Yoneda Y."xsd:string |
| http://purl.uniprot.org/citations/26740045 | http://purl.uniprot.org/core/author | "Tachibana T."xsd:string |
| http://purl.uniprot.org/citations/26740045 | http://purl.uniprot.org/core/author | "Kawakami K."xsd:string |
| http://purl.uniprot.org/citations/26740045 | http://purl.uniprot.org/core/author | "Hirata S."xsd:string |
| http://purl.uniprot.org/citations/26740045 | http://purl.uniprot.org/core/author | "Maehara K."xsd:string |
| http://purl.uniprot.org/citations/26740045 | http://purl.uniprot.org/core/author | "Ohkawa Y."xsd:string |
| http://purl.uniprot.org/citations/26740045 | http://purl.uniprot.org/core/author | "Mura S."xsd:string |
| http://purl.uniprot.org/citations/26740045 | http://purl.uniprot.org/core/author | "Sangel P."xsd:string |
| http://purl.uniprot.org/citations/26740045 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26740045 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/26740045 | http://purl.uniprot.org/core/pages | "e09540"xsd:string |
| http://purl.uniprot.org/citations/26740045 | http://purl.uniprot.org/core/title | "Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes."xsd:string |
| http://purl.uniprot.org/citations/26740045 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/26740045 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26740045 |
| http://purl.uniprot.org/citations/26740045 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26740045 |
| http://purl.uniprot.org/uniprot/#_P52948-mappedCitation-26740045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26740045 |
| http://purl.uniprot.org/uniprot/#_A0A142I7X2-mappedCitation-26740045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26740045 |
| http://purl.uniprot.org/uniprot/#_A0A7I2V2Y6-mappedCitation-26740045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26740045 |
| http://purl.uniprot.org/uniprot/#_A0A7I2V461-mappedCitation-26740045 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26740045 |