| http://purl.uniprot.org/citations/26755705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26755705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26755705 | http://www.w3.org/2000/01/rdf-schema#comment | "T cell immunoglobulin and ITIM domain (TIGIT) and CD226 emerge as a novel T cell cosignaling pathway in which CD226 and TIGIT serve as costimulatory and coinhibitory receptors, respectively, for the ligands CD155 and CD112. In this study, we describe CD112R, a member of poliovirus receptor-like proteins, as a new coinhibitory receptor for human T cells. CD112R is preferentially expressed on T cells and inhibits T cell receptor-mediated signals. We further identify that CD112, widely expressed on antigen-presenting cells and tumor cells, is the ligand for CD112R with high affinity. CD112R competes with CD226 to bind to CD112. Disrupting the CD112R-CD112 interaction enhances human T cell response. Our experiments identify CD112R as a novel checkpoint for human T cells via interaction with CD112."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20150785"xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20150785"xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Yao S."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Yao S."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Bevers S."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Bevers S."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Byers J.T."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Byers J.T."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Edil B.H."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Edil B.H."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Koenig M.R."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Koenig M.R."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Paniccia A."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Paniccia A."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Schulick A.C."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/author | "Schulick A.C."xsd:string |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26755705 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |