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| http://purl.uniprot.org/citations/26760760 | http://www.w3.org/2000/01/rdf-schema#comment | "Drosophila Iroquois (Iro) proteins are components of the TALE homeodomain family of transcriptional regulators. They play key roles in territorial specification and pattern formation. A recent study has disclosed a novel developmental function of the Iro proteins. In the eye and wing imaginal discs, they can regulate the size of the territories that they specify. They do so by cell-autonomously controlling cell cycle progression. Indeed, Iro proteins down-regulate the activity of the CyclinE/Cdk2 complex by a transcription-independent mechanism. This novel function is executed mainly through 2 evolutionarily conserved domains of the Iro proteins: the Cyclin Binding Domain and the IRO-box, which mediate their binding to CyclinE-containing protein complexes. Here we discuss the functional implications of the control of the cell cycle by Iro proteins for development and oncogenesis."xsd:string |
| http://purl.uniprot.org/citations/26760760 | http://purl.org/dc/terms/identifier | "doi:10.1080/19336934.2016.1139654"xsd:string |
| http://purl.uniprot.org/citations/26760760 | http://purl.uniprot.org/core/author | "Campuzano S."xsd:string |
| http://purl.uniprot.org/citations/26760760 | http://purl.uniprot.org/core/author | "Barrios N."xsd:string |
| http://purl.uniprot.org/citations/26760760 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26760760 | http://purl.uniprot.org/core/name | "Fly (Austin)"xsd:string |
| http://purl.uniprot.org/citations/26760760 | http://purl.uniprot.org/core/pages | "126-131"xsd:string |
| http://purl.uniprot.org/citations/26760760 | http://purl.uniprot.org/core/title | "Expanding the Iroquois genes repertoire: a non-transcriptional function in cell cycle progression."xsd:string |
| http://purl.uniprot.org/citations/26760760 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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