| http://purl.uniprot.org/citations/26763345 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26763345 | http://www.w3.org/2000/01/rdf-schema#comment | "In Saccharomyces cerevisiae, the mitochondrial carrier family protein Pic2 imports copper into the matrix. Deletion of PIC2 causes defects in mitochondrial copper uptake and copper-dependent growth phenotypes owing to decreased cytochrome c oxidase activity. However, copper import is not completely eliminated in this mutant, so alternative transport systems must exist. Deletion of MRS3, a component of the iron import machinery, also causes a copper-dependent growth defect on non-fermentable carbon. Deletion of both PIC2 and MRS3 led to a more severe respiratory growth defect than either individual mutant. In addition, MRS3 expressed from a high copy number vector was able to suppress the oxygen consumption and copper uptake defects of a strain lacking PIC2. When expressed in Lactococcus lactis, Mrs3 mediated copper and iron import. Finally, a PIC2 and MRS3 double mutant prevented the copper-dependent activation of a heterologously expressed copper sensor in the mitochondrial intermembrane space. Taken together, these data support a role for the iron transporter Mrs3 in copper import into the mitochondrial matrix."xsd:string |
| http://purl.uniprot.org/citations/26763345 | http://purl.org/dc/terms/identifier | "doi:10.1098/rsob.150223"xsd:string |
| http://purl.uniprot.org/citations/26763345 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/26763345 | http://purl.uniprot.org/core/author | "Cobine P.A."xsd:string |
| http://purl.uniprot.org/citations/26763345 | http://purl.uniprot.org/core/author | "Gammon M.G."xsd:string |
| http://purl.uniprot.org/citations/26763345 | http://purl.uniprot.org/core/author | "Maynard M.K."xsd:string |
| http://purl.uniprot.org/citations/26763345 | http://purl.uniprot.org/core/author | "Vest K.E."xsd:string |
| http://purl.uniprot.org/citations/26763345 | http://purl.uniprot.org/core/author | "Cobine J.A."xsd:string |
| http://purl.uniprot.org/citations/26763345 | http://purl.uniprot.org/core/author | "Mahone W.K."xsd:string |
| http://purl.uniprot.org/citations/26763345 | http://purl.uniprot.org/core/author | "White O.L."xsd:string |
| http://purl.uniprot.org/citations/26763345 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26763345 | http://purl.uniprot.org/core/name | "Open Biol"xsd:string |
| http://purl.uniprot.org/citations/26763345 | http://purl.uniprot.org/core/pages | "150223"xsd:string |
| http://purl.uniprot.org/citations/26763345 | http://purl.uniprot.org/core/title | "Overlap of copper and iron uptake systems in mitochondria in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/26763345 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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