| http://purl.uniprot.org/citations/26764599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26764599 | http://www.w3.org/2000/01/rdf-schema#comment | "Host genes that regulate systemic inflammation upon chronic viral infection are incompletely understood. Murine gammaherpesvirus 68 (MHV68) infection is characterized by latency in macrophages, and reactivation is inhibited by interferon-γ (IFN-γ). Using a lysozyme-M-cre (LysMcre) expression system, we show that deletion of autophagy-related (Atg) genes Fip200, beclin 1, Atg14, Atg16l1, Atg7, Atg3, and Atg5, in the myeloid compartment, inhibited MHV68 reactivation in macrophages. Atg5 deficiency did not alter reactivation from B cells, and effects on reactivation from macrophages were not explained by alterations in productive viral replication or the establishment of latency. Rather, chronic MHV68 infection triggered increased systemic inflammation, increased T cell production of IFN-γ, and an IFN-γ-induced transcriptional signature in macrophages from Atg gene-deficient mice. The Atg5-related reactivation defect was partially reversed by neutralization of IFN-γ. Thus Atg genes in myeloid cells dampen virus-induced systemic inflammation, creating an environment that fosters efficient MHV68 reactivation from latency."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2015.12.010"xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "Park S."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "Levine B."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "Martinez J."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "Virgin H.W."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "Saitoh T."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "Handley S.A."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "Green D.R."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "Artyomov M.N."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "Buck M.D."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "He Y.W."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "Guan J.L."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "Reese T.A."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "Desai C."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "Freeman M.L."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "Blackman M.A."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/author | "Loginicheva E."xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/name | "Cell Host Microbe"xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/pages | "91-101"xsd:string |
| http://purl.uniprot.org/citations/26764599 | http://purl.uniprot.org/core/title | "Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation."xsd:string |