| http://purl.uniprot.org/citations/26765568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26765568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26765568 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitotic spindle orientation is used to generate cell fate diversity and drive proper tissue morphogenesis. A complex of NuMA and dynein/dynactin is required for robust spindle orientation in a number of cell types. Previous research proposed that cortical dynein/dynactin was sufficient to generate forces on astral microtubules (MTs) to orient the spindle, with NuMA acting as a passive tether. In this study, we demonstrate that dynein/dynactin is insufficient for spindle orientation establishment in keratinocytes and that NuMA's MT-binding domain, which targets MT tips, is also required. Loss of NuMA-MT interactions in skin caused defects in spindle orientation and epidermal differentiation, leading to neonatal lethality. In addition, we show that NuMA-MT interactions are also required in adult mice for hair follicle morphogenesis and spindle orientation within the transit-amplifying cells of the matrix. Loss of spindle orientation in matrix cells results in defective differentiation of matrix-derived lineages. Our results reveal an additional and direct function of NuMA during mitotic spindle positioning, as well as a reiterative use of spindle orientation in the skin to build diverse structures."xsd:string |
| http://purl.uniprot.org/citations/26765568 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.12504"xsd:string |
| http://purl.uniprot.org/citations/26765568 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.12504"xsd:string |
| http://purl.uniprot.org/citations/26765568 | http://purl.uniprot.org/core/author | "Seldin L."xsd:string |
| http://purl.uniprot.org/citations/26765568 | http://purl.uniprot.org/core/author | "Seldin L."xsd:string |
| http://purl.uniprot.org/citations/26765568 | http://purl.uniprot.org/core/author | "Lechler T."xsd:string |
| http://purl.uniprot.org/citations/26765568 | http://purl.uniprot.org/core/author | "Lechler T."xsd:string |
| http://purl.uniprot.org/citations/26765568 | http://purl.uniprot.org/core/author | "Muroyama A."xsd:string |
| http://purl.uniprot.org/citations/26765568 | http://purl.uniprot.org/core/author | "Muroyama A."xsd:string |
| http://purl.uniprot.org/citations/26765568 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26765568 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26765568 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/26765568 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/26765568 | http://purl.uniprot.org/core/title | "NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures."xsd:string |
| http://purl.uniprot.org/citations/26765568 | http://purl.uniprot.org/core/title | "NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures."xsd:string |
| http://purl.uniprot.org/citations/26765568 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/26765568 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/26765568 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26765568 |
| http://purl.uniprot.org/citations/26765568 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26765568 |
| http://purl.uniprot.org/citations/26765568 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26765568 |
| http://purl.uniprot.org/citations/26765568 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26765568 |
| http://purl.uniprot.org/uniprot/E9Q7G0 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/26765568 |
| http://purl.uniprot.org/uniprot/Q14980 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/26765568 |