| http://purl.uniprot.org/citations/26768690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26768690 | http://www.w3.org/2000/01/rdf-schema#comment | "HLA molecules play an important role for immunoreactivity in allogeneic hematopoietic stem cell transplantation. To elucidate the effect of specific HLA alleles on acute graft-versus-host disease, we conducted a retrospective analysis using 6967 Japanese patients transplanted with T-cell-replete marrow from an unrelated donor. Using unbiased searches of patient and donor HLA alleles, patient and/or donor HLA-B*51:01 (patient: HR, 1.37,P<0.001; donor: HR, 1.35,P<0.001) and patient HLA-C*14:02 (HR, 1.35,P<0.001) were significantly associated with an increased risk of severe acute graft-versus-host disease. The finding that donor HLA-C*14:02 was not associated with severe acute graft-versus-host disease prompted us to elucidate the relation of these high-risk HLA alleles with patient and donor HLA-C allele mismatches. In comparison to HLA-C allele match, patient mismatched HLA-C*14:02 showed the highest risk of severe acute graft-versus-host disease (HR, 3.61,P<0.001) and transplant-related mortality (HR, 2.53,P<0.001) among all patient mismatched HLA-C alleles. Although patient HLA-C*14:02 and donor HLA-C*15:02 mismatch was usually KIR2DL-ligand mismatch in the graft-versus-host direction, the risk of patient mismatched HLA-C*14:02 for severe acute graft-versus-host disease was obvious regardless of KIR2DL-ligand matching. The effect of patient and/or donor HLA-B*51:01 on acute graft-versus-host disease was attributed not only to strong linkage disequilibrium of HLA-C*14:02 and -B*51:01, but also to the effect of HLA-B*51:01 itself. With regard to clinical implications, patient mismatched HLA-C*14:02 proved to be a potent risk factor for severe acute graft-versus-host disease and mortality, and should be considered a non-permissive HLA-C mismatch in donor selection for unrelated donor hematopoietic stem cell transplantation."xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.org/dc/terms/identifier | "doi:10.3324/haematol.2015.136903"xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/author | "Kato S."xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/author | "Matsuo K."xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/author | "Ogawa S."xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/author | "Shiina T."xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/author | "Yabe T."xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/author | "Morishima S."xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/author | "Satake M."xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/author | "Sasazuki T."xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/author | "Saji H."xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/author | "Kodera Y."xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/author | "Morishima Y."xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/author | "Kashiwase K."xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/author | "Sato-Otsubo A."xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/author | "Azuma F."xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/name | "Haematologica"xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/pages | "491-498"xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/title | "High-risk HLA alleles for severe acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation."xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/26768690 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26768690 |
| http://purl.uniprot.org/citations/26768690 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26768690 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C549-mappedCitation-26768690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26768690 |