http://purl.uniprot.org/citations/26769066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/26769066 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundGenetic ancestry, sex, and individual alleles have been associated with multiple sclerosis (MS) susceptibility.ObjectiveTo determine whether established risk factors for disease onset are associated with relapse rate in pediatric MS.MethodsWhole-genome genotyping was performed for 181 MS or high-risk clinically isolated syndrome patients from two pediatric MS centers. Relapses and disease-modifying therapies were recorded as part of continued follow-up. Participants were characterized for 25-hydroxyvitamin D serum status. Ancestral estimates (STRUCTURE v2.3.1), human leukocyte antigen (HLA)-DRB1*15 carrier status (direct sequencing), sex, and a genetic risk score (GRS) of 110 non-HLA susceptibility single-nucleotide polymorphisms (SNPs) were evaluated for association with relapse rate with Cox and negative binomial regression models.ResultsOver 622 patient-years, 408 relapses were captured. Girls had greater relapse rate than boys (incident rate ratio (IRR) = 1.40, 95% confidence interval (CI) = 1.04-1.87, p = 0.026). Participants were genetically diverse; ~40% (N = 75) had <50% European ancestry. HLA-DRB1*15 status modified the association of vitamin D status (pixn = 0.022) with relapse rate (per 10 ng/mL, in DRB1*15+ hazard ratio (HR) = 0.72, 95% CI = 0.58-0.88, p = 0.002; in DRB1*15-HR = 0.96, 95% CI = 0.83-1.12, p = 0.64). Neither European ancestry nor GRS was associated with relapse rate.ConclusionWe demonstrate that HLA-DRB1*15 modifies the association of vitamin D status with relapse rate. Our findings emphasize the need to pursue disease-modifying effects of MS genes in the context of environmental factors."xsd:string |
http://purl.uniprot.org/citations/26769066 | http://purl.org/dc/terms/identifier | "doi:10.1177/1352458515624269"xsd:string |
http://purl.uniprot.org/citations/26769066 | http://purl.uniprot.org/core/author | "Shao X."xsd:string |
http://purl.uniprot.org/citations/26769066 | http://purl.uniprot.org/core/author | "Quach H."xsd:string |
http://purl.uniprot.org/citations/26769066 | http://purl.uniprot.org/core/author | "Barcellos L.F."xsd:string |
http://purl.uniprot.org/citations/26769066 | http://purl.uniprot.org/core/author | "Noble J."xsd:string |
http://purl.uniprot.org/citations/26769066 | http://purl.uniprot.org/core/author | "Mowry E.M."xsd:string |
http://purl.uniprot.org/citations/26769066 | http://purl.uniprot.org/core/author | "Waubant E."xsd:string |
http://purl.uniprot.org/citations/26769066 | http://purl.uniprot.org/core/author | "Belman A."xsd:string |
http://purl.uniprot.org/citations/26769066 | http://purl.uniprot.org/core/author | "Casper T.C."xsd:string |
http://purl.uniprot.org/citations/26769066 | http://purl.uniprot.org/core/author | "Graves J.S."xsd:string |
http://purl.uniprot.org/citations/26769066 | http://purl.uniprot.org/core/author | "Krupp L.B."xsd:string |
http://purl.uniprot.org/citations/26769066 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
http://purl.uniprot.org/citations/26769066 | http://purl.uniprot.org/core/name | "Mult Scler"xsd:string |
http://purl.uniprot.org/citations/26769066 | http://purl.uniprot.org/core/pages | "1528-1535"xsd:string |
http://purl.uniprot.org/citations/26769066 | http://purl.uniprot.org/core/title | "Genetic predictors of relapse rate in pediatric MS."xsd:string |
http://purl.uniprot.org/citations/26769066 | http://purl.uniprot.org/core/volume | "22"xsd:string |
http://purl.uniprot.org/citations/26769066 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26769066 |
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