| http://purl.uniprot.org/citations/26771544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26771544 | http://www.w3.org/2000/01/rdf-schema#comment | "The C. elegans AWC olfactory neuron pair communicates to specify asymmetric subtypes AWCOFF and AWCON in a stochastic manner. Intercellular communication between AWC and other neurons in a transient NSY-5 gap junction network antagonizes voltage-activated calcium channels, UNC-2 (CaV2) and EGL-19 (CaV1), in the AWCON cell, but how calcium signaling is downregulated by NSY-5 is only partly understood. Here, we show that voltage- and calcium-activated SLO BK potassium channels mediate gap junction signaling to inhibit calcium pathways for asymmetric AWC differentiation. Activation of vertebrate SLO-1 channels causes transient membrane hyperpolarization, which makes it an important negative feedback system for calcium entry through voltage-activated calcium channels. Consistent with the physiological roles of SLO-1, our genetic results suggest that slo-1 BK channels act downstream of NSY-5 gap junctions to inhibit calcium channel-mediated signaling in the specification of AWCON. We also show for the first time that slo-2 BK channels are important for AWC asymmetry and act redundantly with slo-1 to inhibit calcium signaling. In addition, nsy-5-dependent asymmetric expression of slo-1 and slo-2 in the AWCON neuron is necessary and sufficient for AWC asymmetry. SLO-1 and SLO-2 localize close to UNC-2 and EGL-19 in AWC, suggesting a role of possible functional coupling between SLO BK channels and voltage-activated calcium channels in AWC asymmetry. Furthermore, slo-1 and slo-2 regulate the localization of synaptic markers, UNC-2 and RAB-3, in AWC neurons to control AWC asymmetry. We also identify the requirement of bkip-1, which encodes a previously identified auxiliary subunit of SLO-1, for slo-1 and slo-2 function in AWC asymmetry. Together, these results provide an unprecedented molecular link between gap junctions and calcium pathways for terminal differentiation of olfactory neurons."xsd:string |
| http://purl.uniprot.org/citations/26771544 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1005654"xsd:string |
| http://purl.uniprot.org/citations/26771544 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/26771544 | http://purl.uniprot.org/core/author | "Jorgensen E.M."xsd:string |
| http://purl.uniprot.org/citations/26771544 | http://purl.uniprot.org/core/author | "Merrill S.A."xsd:string |
| http://purl.uniprot.org/citations/26771544 | http://purl.uniprot.org/core/author | "Chuang C.F."xsd:string |
| http://purl.uniprot.org/citations/26771544 | http://purl.uniprot.org/core/author | "Alqadah A."xsd:string |
| http://purl.uniprot.org/citations/26771544 | http://purl.uniprot.org/core/author | "Hsieh Y.W."xsd:string |
| http://purl.uniprot.org/citations/26771544 | http://purl.uniprot.org/core/author | "Schumacher J.A."xsd:string |
| http://purl.uniprot.org/citations/26771544 | http://purl.uniprot.org/core/author | "Millington G."xsd:string |
| http://purl.uniprot.org/citations/26771544 | http://purl.uniprot.org/core/author | "Bayne B."xsd:string |
| http://purl.uniprot.org/citations/26771544 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26771544 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/26771544 | http://purl.uniprot.org/core/pages | "e1005654"xsd:string |
| http://purl.uniprot.org/citations/26771544 | http://purl.uniprot.org/core/title | "SLO BK Potassium Channels Couple Gap Junctions to Inhibition of Calcium Signaling in Olfactory Neuron Diversification."xsd:string |
| http://purl.uniprot.org/citations/26771544 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/26771544 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26771544 |
| http://purl.uniprot.org/citations/26771544 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26771544 |
| http://purl.uniprot.org/uniprot/#_A0A3B1DR32-mappedCitation-26771544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771544 |
| http://purl.uniprot.org/uniprot/#_A0A3B1E4Z9-mappedCitation-26771544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771544 |
| http://purl.uniprot.org/uniprot/#_A0A3B1E663-mappedCitation-26771544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771544 |
| http://purl.uniprot.org/uniprot/#_A0A3B1E695-mappedCitation-26771544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771544 |
| http://purl.uniprot.org/uniprot/#_A0A1N7SYT0-mappedCitation-26771544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771544 |
| http://purl.uniprot.org/uniprot/#_A0A1N7SYT1-mappedCitation-26771544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771544 |