| http://purl.uniprot.org/citations/26771829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26771829 | http://www.w3.org/2000/01/rdf-schema#comment | "Bang sensitive (BS) Drosophila mutants display characteristic seizure-like phenotypes resembling, in some aspects, those of human seizure disorders such as epilepsy. The BS mutant parabss1, caused by a gain-of-function mutation of the voltage-gated Na+ channel gene, is extremely seizure-sensitive with phenotypes that have proven difficult to ameliorate by anti-epileptic drug feeding or by seizure-suppressor mutation. It has been presented as a model for intractable human epilepsy. Here we show that cacophony (cacTS2), a mutation of the Drosophila presynaptic Ca++ channel α1 subunit gene, is a particularly potent seizure-suppressor mutation, reverting seizure-like phenotypes for parabss1 and other BS mutants. Seizure-like phenotypes for parabss1 may be suppressed by as much as 90% in double mutant combinations with cacTS2. Unexpectedly, we find that parabss1 also reciprocally suppresses cacTS2 seizure-like phenotypes. The cacTS2 mutant displays these seizure-like behaviors and spontaneous high-frequency action potential firing transiently after exposure to high temperature. We find that this seizure-like behavior in cacTS2 is ameliorated by 85% in double mutant combinations with parabss1."xsd:string |
| http://purl.uniprot.org/citations/26771829 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1005784"xsd:string |
| http://purl.uniprot.org/citations/26771829 | http://purl.uniprot.org/core/author | "Tanouye M.A."xsd:string |
| http://purl.uniprot.org/citations/26771829 | http://purl.uniprot.org/core/author | "Saras A."xsd:string |
| http://purl.uniprot.org/citations/26771829 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26771829 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/26771829 | http://purl.uniprot.org/core/pages | "e1005784"xsd:string |
| http://purl.uniprot.org/citations/26771829 | http://purl.uniprot.org/core/title | "Mutations of the Calcium Channel Gene cacophony Suppress Seizures in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/26771829 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/26771829 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26771829 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KHT8-mappedCitation-26771829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771829 |
| http://purl.uniprot.org/uniprot/#_P54352-mappedCitation-26771829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771829 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHA7-mappedCitation-26771829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771829 |
| http://purl.uniprot.org/uniprot/#_A0A4D6K1U1-mappedCitation-26771829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771829 |
| http://purl.uniprot.org/uniprot/#_A0A4D6K2Y1-mappedCitation-26771829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771829 |
| http://purl.uniprot.org/uniprot/#_A0A4D6K2Y3-mappedCitation-26771829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771829 |
| http://purl.uniprot.org/uniprot/#_B7Z0Z2-mappedCitation-26771829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771829 |
| http://purl.uniprot.org/uniprot/#_M9MSE4-mappedCitation-26771829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771829 |
| http://purl.uniprot.org/uniprot/#_M9MSE6-mappedCitation-26771829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771829 |
| http://purl.uniprot.org/uniprot/#_M9MSE7-mappedCitation-26771829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771829 |
| http://purl.uniprot.org/uniprot/#_M9MSE9-mappedCitation-26771829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771829 |
| http://purl.uniprot.org/uniprot/#_M9MSF1-mappedCitation-26771829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771829 |
| http://purl.uniprot.org/uniprot/#_M9MSF2-mappedCitation-26771829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26771829 |