| http://purl.uniprot.org/citations/26773047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26773047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26773047 | http://www.w3.org/2000/01/rdf-schema#comment | "Lipids play a pivotal role in embryogenesis as structural components of cellular membranes, as a source of energy, and as signaling molecules. On the basis of a collection of temperature-sensitive embryonic lethal mutants, a systematic database search, and a subsequent microscopic analysis of >300 interference RNA (RNAi)-treated/mutant worms, we identified a couple of evolutionary conserved genes associated with lipid storage in Caenorhabditis elegans embryos. The genes include cpl-1 (cathepsin L-like cysteine protease), ccz-1 (guanine nucleotide exchange factor subunit), and asm-3 (acid sphingomyelinase), which is closely related to the human Niemann-Pick disease-causing gene SMPD1. The respective mutant embryos accumulate enlarged droplets of neutral lipids (cpl-1) and yolk-containing lipid droplets (ccz-1) or have larger genuine lipid droplets (asm-3). The asm-3 mutant embryos additionally showed an enhanced resistance against C band ultraviolet (UV-C) light. Herein we propose that cpl-1, ccz-1, and asm-3 are genes required for the processing of lipid-containing droplets in C. elegans embryos. Owing to the high levels of conservation, the identified genes are also useful in studies of embryonic lipid storage in other organisms."xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.115.179127"xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.115.179127"xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/author | "Doering F."xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/author | "Doering F."xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/author | "Schnabel R."xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/author | "Schnabel R."xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/author | "Memar N."xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/author | "Memar N."xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/author | "Schmoekel V."xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/author | "Schmoekel V."xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/author | "Trotzmueller M."xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/author | "Trotzmueller M."xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/author | "Wiekenberg A."xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/author | "Wiekenberg A."xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/pages | "1071-1083"xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/pages | "1071-1083"xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/title | "Genetics of Lipid-Storage Management in Caenorhabditis elegans Embryos."xsd:string |
| http://purl.uniprot.org/citations/26773047 | http://purl.uniprot.org/core/title | "Genetics of Lipid-Storage Management in Caenorhabditis elegans Embryos."xsd:string |