| http://purl.uniprot.org/citations/26776159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26776159 | http://www.w3.org/2000/01/rdf-schema#comment | "Genome-wide chromatin studies identified the tumor suppressor p53 as both a promoter and an enhancer-binding transcription factor. As an enhancer factor, p53 can induce local production of enhancer RNAs, as well as transcriptional activation of distal neighboring genes. Beyond the regulation of protein-coding genes, p53 has the capacity to regulate long intergenic noncoding RNA molecules (lincRNAs); however, their importance to the p53 tumor suppressive function remains poorly characterized. Here, we identified and characterized a novel p53-bound intronic enhancer that controls the expression of its host, the lincRNA00475 (linc-475). We demonstrate the requirement of linc-475 for the proper induction of a p53-dependent cell cycle inhibitory response. We further confirm the functional importance of linc-475 in the maintenance of CDKN1A/p21 levels, a cell cycle inhibitor and a major p53 target gene, following p53 activation. Interestingly, loss of linc-475 reduced the binding of both p53 and RNA polymerase II (RNAPII) to the promoter of p21, attenuating its transcription rate following p53 activation. Altogether, our data suggest a direct role of p53-bound enhancer domains in the activation of lincRNAs required for an efficient p53 transcriptional response."xsd:string |
| http://purl.uniprot.org/citations/26776159 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2015.502"xsd:string |
| http://purl.uniprot.org/citations/26776159 | http://purl.uniprot.org/core/author | "Agami R."xsd:string |
| http://purl.uniprot.org/citations/26776159 | http://purl.uniprot.org/core/author | "Geeven G."xsd:string |
| http://purl.uniprot.org/citations/26776159 | http://purl.uniprot.org/core/author | "Leveille N."xsd:string |
| http://purl.uniprot.org/citations/26776159 | http://purl.uniprot.org/core/author | "de Laat W."xsd:string |
| http://purl.uniprot.org/citations/26776159 | http://purl.uniprot.org/core/author | "Melo S.A."xsd:string |
| http://purl.uniprot.org/citations/26776159 | http://purl.uniprot.org/core/author | "Melo C.A."xsd:string |
| http://purl.uniprot.org/citations/26776159 | http://purl.uniprot.org/core/author | "Tal A."xsd:string |
| http://purl.uniprot.org/citations/26776159 | http://purl.uniprot.org/core/author | "Wijchers P.J."xsd:string |
| http://purl.uniprot.org/citations/26776159 | http://purl.uniprot.org/core/author | "Rooijers K."xsd:string |
| http://purl.uniprot.org/citations/26776159 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26776159 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/26776159 | http://purl.uniprot.org/core/pages | "4399-4406"xsd:string |
| http://purl.uniprot.org/citations/26776159 | http://purl.uniprot.org/core/title | "A p53-bound enhancer region controls a long intergenic noncoding RNA required for p53 stress response."xsd:string |
| http://purl.uniprot.org/citations/26776159 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/26776159 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26776159 |
| http://purl.uniprot.org/citations/26776159 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26776159 |
| http://purl.uniprot.org/uniprot/#_A0A0A0U7X4-mappedCitation-26776159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26776159 |
| http://purl.uniprot.org/uniprot/#_A0A0M4B4Y9-mappedCitation-26776159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26776159 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-26776159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26776159 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-26776159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26776159 |
| http://purl.uniprot.org/uniprot/#_A0A0C4L134-mappedCitation-26776159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26776159 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-26776159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26776159 |