| http://purl.uniprot.org/citations/26777750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26777750 | http://www.w3.org/2000/01/rdf-schema#comment | "Allergic contact hypersensitivity (CHS) is an inflammatory skin disease mediated by allergen specific T cells. In this study, we investigated the role of transcription factor NFAT1 in the pathogenesis of contact hypersensitivity. NFAT1 knock out (KO) mice spontaneously developed CHS-like skin inflammation in old age. Healthy young NFAT1 KO mice displayed enhanced susceptibility to hapten-induced CHS. Both CD4(+) and CD8(+) T cells from NFAT1 KO mice displayed hyper-activated properties and produced significantly enhanced levels of inflammatory T helper 1(Th1)/Th17 type cytokines. NFAT1 KO T cells were more resistant to activation induced cell death (AICD), and regulatory T cells derived from these mice showed a partial defect in their suppressor activity. NFAT1 KO T cells displayed a reduced expression of apoptosis associated BCL-2/BH3 family members. Ectopic expression of NFAT1 restored the AICD defect in NFAT1 KO T cells and increased AICD in normal T cells. Recipient Rag2(-/-) mice transferred with NFAT1 KO T cells showed more severe CHS sensitivity due to a defect in activation induced hapten-reactive T cell apoptosis. Collectively, our results suggest the NFAT1 plays a pivotal role as a genetic switch in CD4(+)/CD8(+) T cell tolerance by regulating AICD process in the T cell mediated skin inflammation."xsd:string |
| http://purl.uniprot.org/citations/26777750 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep19453"xsd:string |
| http://purl.uniprot.org/citations/26777750 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/26777750 | http://purl.uniprot.org/core/author | "Hwang J.S."xsd:string |
| http://purl.uniprot.org/citations/26777750 | http://purl.uniprot.org/core/author | "Im S.H."xsd:string |
| http://purl.uniprot.org/citations/26777750 | http://purl.uniprot.org/core/author | "Nam J.H."xsd:string |
| http://purl.uniprot.org/citations/26777750 | http://purl.uniprot.org/core/author | "Jun C.D."xsd:string |
| http://purl.uniprot.org/citations/26777750 | http://purl.uniprot.org/core/author | "Surh C.D."xsd:string |
| http://purl.uniprot.org/citations/26777750 | http://purl.uniprot.org/core/author | "Kwon H.K."xsd:string |
| http://purl.uniprot.org/citations/26777750 | http://purl.uniprot.org/core/author | "Chae C.S."xsd:string |
| http://purl.uniprot.org/citations/26777750 | http://purl.uniprot.org/core/author | "Rudra D."xsd:string |
| http://purl.uniprot.org/citations/26777750 | http://purl.uniprot.org/core/author | "Kim G.C."xsd:string |
| http://purl.uniprot.org/citations/26777750 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26777750 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/26777750 | http://purl.uniprot.org/core/pages | "19453"xsd:string |
| http://purl.uniprot.org/citations/26777750 | http://purl.uniprot.org/core/title | "Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program."xsd:string |
| http://purl.uniprot.org/citations/26777750 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26777750 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26777750 |
| http://purl.uniprot.org/citations/26777750 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26777750 |
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| http://purl.uniprot.org/uniprot/#_B5B2P6-mappedCitation-26777750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26777750 |
| http://purl.uniprot.org/uniprot/#_B5B2P7-mappedCitation-26777750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26777750 |
| http://purl.uniprot.org/uniprot/#_B5B2P8-mappedCitation-26777750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26777750 |
| http://purl.uniprot.org/uniprot/#_B5B2Q2-mappedCitation-26777750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26777750 |