| http://purl.uniprot.org/citations/26778124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26778124 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulation of 5' end resection at DSBs and telomeres prevents genome instability. DSB resection is positively and negatively regulated by ATM signaling through CtIP/MRN and 53BP1-bound Rif1, respectively. Similarly, telomeres lacking TRF2 undergo ATM-controlled CtIP-dependent hyper-resection when the repression by 53BP1/Rif1 is alleviated. However, telomere resection in the absence of 53BP1/Rif1 is more extensive upon complete removal of shelterin, indicating additional protection against resection by shelterin. Here we show that TPP1 and POT1a/b in shelterin block a resection pathway distinct from that repressed by TRF2. This second pathway is regulated by ATR signaling, involves Exo1 and BLM, and is inhibited by 53BP1/Rif1. Thus, mammalian cells have two distinct 5' end-resection pathways that are regulated by DNA damage signaling, in part through Rif1-mediated inhibition. The data show that telomeres are protected from hyper-resection through the repression of the ATM and ATR kinases by TRF2 and TPP1-bound POT1a/b, respectively."xsd:string |
| http://purl.uniprot.org/citations/26778124 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2015.12.016"xsd:string |
| http://purl.uniprot.org/citations/26778124 | http://purl.uniprot.org/core/author | "Zimmermann M."xsd:string |
| http://purl.uniprot.org/citations/26778124 | http://purl.uniprot.org/core/author | "de Lange T."xsd:string |
| http://purl.uniprot.org/citations/26778124 | http://purl.uniprot.org/core/author | "Kibe T."xsd:string |
| http://purl.uniprot.org/citations/26778124 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26778124 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/26778124 | http://purl.uniprot.org/core/pages | "236-246"xsd:string |
| http://purl.uniprot.org/citations/26778124 | http://purl.uniprot.org/core/title | "TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres."xsd:string |
| http://purl.uniprot.org/citations/26778124 | http://purl.uniprot.org/core/volume | "61"xsd:string |
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