| http://purl.uniprot.org/citations/26783937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26783937 | http://www.w3.org/2000/01/rdf-schema#comment | "EPAS-1/HIF-2α (Endothelial PAS domain-containing protein 1/hypoxia-inducible transcription factors 2α) is a transcription factor expressed in a wide range of human cancers, including stomach cancer. Although EPAS-1 has been studied for years, its function in oncogenic transformation processes needs to be further investigated. In this study, we found that EPAS-1 would promote the growth of stomach cancer cell line BGC-823. Our results revealed that EPAS-1 interacts with Pregnane X Receptor (PXR), a nuclear receptor that regulates multiple genes' transcription involved in multi-drugs resistance (MDR) process. Protein-protein interaction between EPAS-1 and PXR was identified by co-immunoprecipitation and GST-pull down assays. By this interaction, EPAS-1 recruited PXR to its response elements in promoter/enhancer regions of CYP3A4, a PXR target gene. Over-expression of EPAS-1 increased the expression of PXR responsive genes, enhanced the proliferation of BGC-823 cells and boosted the resistance of BGC-823 cells against the cytotoxicity of chemotherapeutic drugs, e.g. Mitomycin C and Paclitaxel. Reduction of EPAS-1 level via its siRNA disrupted the proliferation, and enhanced the susceptibility of BGC-823 cells to those chemotherapeutic drugs. Our findings suggested that EPAS-1 and PXR may cooperatively participate in development and especially MDR process of stomach cancer. These findings may contribute to more effective targeted drugs discovery for the stomach cancer therapy."xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biocel.2016.01.006"xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://purl.uniprot.org/core/author | "Du F."xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://purl.uniprot.org/core/author | "Li G."xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://purl.uniprot.org/core/author | "Ma X."xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://purl.uniprot.org/core/author | "Shen G."xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://purl.uniprot.org/core/author | "Xu B."xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://purl.uniprot.org/core/author | "Zhao J.'"xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://purl.uniprot.org/core/author | "Bai Z."xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://purl.uniprot.org/core/author | "Song E."xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://purl.uniprot.org/core/author | "Hang X."xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://purl.uniprot.org/core/author | "Feng F."xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://purl.uniprot.org/core/author | "Ji F."xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26783937 | http://purl.uniprot.org/core/name | "Int J Biochem Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://purl.uniprot.org/core/pages | "73-88"xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://purl.uniprot.org/core/title | "Cross-talk between EPAS-1/HIF-2alpha and PXR signaling pathway regulates multi-drug resistance of stomach cancer cell."xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://purl.uniprot.org/core/volume | "72"xsd:string |
| http://purl.uniprot.org/citations/26783937 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26783937 |
| http://purl.uniprot.org/citations/26783937 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26783937 |
| http://purl.uniprot.org/uniprot/#_B3KW07-mappedCitation-26783937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26783937 |
| http://purl.uniprot.org/uniprot/#_B3KVM5-mappedCitation-26783937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26783937 |
| http://purl.uniprot.org/uniprot/#_B6ZGT1-mappedCitation-26783937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26783937 |