| http://purl.uniprot.org/citations/26786105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26786105 | http://www.w3.org/2000/01/rdf-schema#comment | "The I-κB kinase (IKK) subunit NEMO/IKKγ (NEMO) is an adapter molecule that is critical for canonical activation of NF-κB, a pleiotropic transcription factor controlling immunity, differentiation, cell growth, tumorigenesis, and apoptosis. To explore the functional role of canonical NF-κB signaling in thyroid gland differentiation and function, we have generated a murine strain bearing a genetic deletion of the NEMO locus in thyroid. Here we show that thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after birth, which leads to reduced body weight and shortened life span. Histological and molecular analysis indicate that absence of NEMO in thyrocytes results in a dramatic loss of the thyroid gland cellularity, associated with down-regulation of thyroid differentiation markers and ongoing apoptosis. Thus, NEMO-dependent signaling is essential for normal thyroid physiology."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m115.711697"xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/author | "Vito P."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/author | "Leonardi A."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/author | "Ferravante A."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/author | "Scudiero I."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/author | "Stilo R."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/author | "Zotti T."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/author | "Pasparakis M."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/author | "Reale C."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/author | "Zannini M."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/author | "Iervolino A."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/author | "de Cristofaro T."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/author | "Capasso G."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/author | "Mazzone P."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/author | "Shanmugakonar M."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/author | "D'Andrea L.E."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/author | "Roberto L."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/pages | "5765-5773"xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/title | "NF-kappaB Essential Modulator (NEMO) Is Critical for Thyroid Function."xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://purl.uniprot.org/core/volume | "291"xsd:string |
| http://purl.uniprot.org/citations/26786105 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26786105 |