| http://purl.uniprot.org/citations/26787722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26787722 | http://www.w3.org/2000/01/rdf-schema#comment | "Coxiella burnetii, the causative agent of Q fever, is an obligate intracellular, primarily pulmonary, bacterial pathogen. Although much is known about adaptive immune responses against this bacterium, our understanding of innate immune responses against C. burnetii is not well defined, particularly within the target tissue for infection, the lung. Previous studies examined the roles of the innate immune system receptors Toll-like receptor 2 (TLR2) and TLR4 in peripheral infection models and described minimal phenotypes in specific gene deletion animals compared to those of their wild-type controls (S. Meghari et al., Ann N Y Acad Sci 1063:161-166, 2005,http://dx.doi.org/10.1196/annals.1355.025; A. Honstettre et al., J Immunol 172:3695-3703, 2004,http://dx.doi.org/10.4049/jimmunol.172.6.3695) . Here, we assessed the roles for TLR2, TLR4, and MyD88 in pulmonary C. burnetii infection and compared responses to those that occurred in TLR2- and TLR4-deficient animals following peripheral infection. As observed previously, neither TLR2 nor TLR4 was needed for limiting bacterial growth after peripheral infection. In contrast, TLR2 and, to a lesser extent, TLR4 limited growth (or dissemination) of the bacterium in the lung and spleen after pulmonary infection. TLR2, TLR4, and MyD88 were not required for the general inflammatory response in the lungs after pulmonary infection. However, MyD88 signaling was important for infection-induced morbidity. Finally, TLR2 expression on hematopoietic cells was most important for limiting bacterial growth in the lung. These results expand on our knowledge of the roles for TLR2 and TLR4 in C. burnetii infection and suggest various roles for these receptors that are dictated by the site of infection."xsd:string |
| http://purl.uniprot.org/citations/26787722 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.00898-15"xsd:string |
| http://purl.uniprot.org/citations/26787722 | http://purl.uniprot.org/core/author | "Lubick K.J."xsd:string |
| http://purl.uniprot.org/citations/26787722 | http://purl.uniprot.org/core/author | "Jerome M."xsd:string |
| http://purl.uniprot.org/citations/26787722 | http://purl.uniprot.org/core/author | "Hedges J.F."xsd:string |
| http://purl.uniprot.org/citations/26787722 | http://purl.uniprot.org/core/author | "Jutila M.A."xsd:string |
| http://purl.uniprot.org/citations/26787722 | http://purl.uniprot.org/core/author | "Robison A."xsd:string |
| http://purl.uniprot.org/citations/26787722 | http://purl.uniprot.org/core/author | "Freedman B."xsd:string |
| http://purl.uniprot.org/citations/26787722 | http://purl.uniprot.org/core/author | "Blackwell A."xsd:string |
| http://purl.uniprot.org/citations/26787722 | http://purl.uniprot.org/core/author | "Ramstead A.G."xsd:string |
| http://purl.uniprot.org/citations/26787722 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26787722 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/26787722 | http://purl.uniprot.org/core/pages | "940-949"xsd:string |
| http://purl.uniprot.org/citations/26787722 | http://purl.uniprot.org/core/title | "Roles of Toll-Like Receptor 2 (TLR2), TLR4, and MyD88 during Pulmonary Coxiella burnetii Infection."xsd:string |
| http://purl.uniprot.org/citations/26787722 | http://purl.uniprot.org/core/volume | "84"xsd:string |
| http://purl.uniprot.org/citations/26787722 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26787722 |
| http://purl.uniprot.org/citations/26787722 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26787722 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-26787722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26787722 |
| http://purl.uniprot.org/uniprot/#_Q0PM16-mappedCitation-26787722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26787722 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLE4-mappedCitation-26787722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26787722 |
| http://purl.uniprot.org/uniprot/#_A2BHU8-mappedCitation-26787722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26787722 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLF0-mappedCitation-26787722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26787722 |
| http://purl.uniprot.org/uniprot/#_F6SPW1-mappedCitation-26787722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26787722 |
| http://purl.uniprot.org/uniprot/#_G3X8Y8-mappedCitation-26787722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26787722 |