| http://purl.uniprot.org/citations/26788497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26788497 | http://www.w3.org/2000/01/rdf-schema#comment | "The development of the B-lymphoid cell lineage is tightly controlled by the concerted action of a network of transcriptional and epigenetic regulators. EBF1, a central component of this network, is essential for B-lymphoid specification and commitment as well as for the maintenance of the B-cell identity. Genetic alterations causing loss of function of these B-lymphopoiesis regulators have been implicated in the pathogenesis of B-lymphoid malignancies, with particular regard to B-cell acute lymphoblastic leukaemias (B-ALLs), where their presence is frequently detected. The activity of the B-cell regulatory network may also be disrupted by the aberrant expression of inhibitory molecules. In particular, two multi-zinc finger transcription cofactors named ZNF423 and ZNF521 have been characterised as potent inhibitors of EBF1 and are emerging as potentially relevant contributors to the development of B-cell leukaemias. Here we will briefly review the current knowledge of these factors and discuss the importance of their functional cross talk with EBF1 in the development of B-cell malignancies."xsd:string |
| http://purl.uniprot.org/citations/26788497 | http://purl.org/dc/terms/identifier | "doi:10.1155/2015/165238"xsd:string |
| http://purl.uniprot.org/citations/26788497 | http://purl.uniprot.org/core/author | "Bond H.M."xsd:string |
| http://purl.uniprot.org/citations/26788497 | http://purl.uniprot.org/core/author | "Mesuraca M."xsd:string |
| http://purl.uniprot.org/citations/26788497 | http://purl.uniprot.org/core/author | "Morrone G."xsd:string |
| http://purl.uniprot.org/citations/26788497 | http://purl.uniprot.org/core/author | "Giordano M."xsd:string |
| http://purl.uniprot.org/citations/26788497 | http://purl.uniprot.org/core/author | "Chiarella E."xsd:string |
| http://purl.uniprot.org/citations/26788497 | http://purl.uniprot.org/core/author | "Nappo G."xsd:string |
| http://purl.uniprot.org/citations/26788497 | http://purl.uniprot.org/core/author | "Scicchitano S."xsd:string |
| http://purl.uniprot.org/citations/26788497 | http://purl.uniprot.org/core/author | "Codispoti B."xsd:string |
| http://purl.uniprot.org/citations/26788497 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/26788497 | http://purl.uniprot.org/core/name | "Biomed Res Int"xsd:string |
| http://purl.uniprot.org/citations/26788497 | http://purl.uniprot.org/core/pages | "165238"xsd:string |
| http://purl.uniprot.org/citations/26788497 | http://purl.uniprot.org/core/title | "ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies."xsd:string |
| http://purl.uniprot.org/citations/26788497 | http://purl.uniprot.org/core/volume | "2015"xsd:string |
| http://purl.uniprot.org/citations/26788497 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26788497 |
| http://purl.uniprot.org/citations/26788497 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26788497 |
| http://purl.uniprot.org/uniprot/#_A8K0Z7-mappedCitation-26788497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26788497 |
| http://purl.uniprot.org/uniprot/#_A8KAK2-mappedCitation-26788497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26788497 |
| http://purl.uniprot.org/uniprot/#_B3KNG7-mappedCitation-26788497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26788497 |
| http://purl.uniprot.org/uniprot/#_B4E172-mappedCitation-26788497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26788497 |
| http://purl.uniprot.org/uniprot/#_B7Z9C7-mappedCitation-26788497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26788497 |
| http://purl.uniprot.org/uniprot/#_B4E2U8-mappedCitation-26788497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26788497 |
| http://purl.uniprot.org/uniprot/#_F5H7S1-mappedCitation-26788497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26788497 |