| http://purl.uniprot.org/citations/26791245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26791245 | http://www.w3.org/2000/01/rdf-schema#comment | "The signalling mechanisms of costimulation in the development of memory T cells remain to be clarified. Here, we show that the transcription factor c-Myc in CD8(+) T cells is controlled by costimulatory molecules, which modulates the development of memory CD8(+) T cells. C-Myc expression was dramatically reduced in Cd28(-/-) or Ox40(-/-) memory CD8(+) T cells, and c-Myc over-expression substantially reversed the defects in the development of T-cell memory following viral infection. C-Myc regulated the expression of survivin, an inhibitor of apoptosis, which promoted the generation of virus-specific memory CD8(+) T cells. Moreover, over-expression of survivin with bcl-xL, a downstream molecule of NF-κB and intracellular target of costimulation that controls survival, in Cd28(-/-) or Ox40(-/-) CD8(+) T cells, reversed the defects in the generation of memory T cells in response to viral infection. These results identify c-Myc as a key controller of memory CD8(+) T cells from costimulatory signals."xsd:string |
| http://purl.uniprot.org/citations/26791245 | http://purl.org/dc/terms/identifier | "doi:10.1098/rsob.150208"xsd:string |
| http://purl.uniprot.org/citations/26791245 | http://purl.uniprot.org/core/author | "Song X."xsd:string |
| http://purl.uniprot.org/citations/26791245 | http://purl.uniprot.org/core/author | "Song J."xsd:string |
| http://purl.uniprot.org/citations/26791245 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/26791245 | http://purl.uniprot.org/core/author | "Fang D."xsd:string |
| http://purl.uniprot.org/citations/26791245 | http://purl.uniprot.org/core/author | "Haque M."xsd:string |
| http://purl.uniprot.org/citations/26791245 | http://purl.uniprot.org/core/author | "Salek-Ardakani S."xsd:string |
| http://purl.uniprot.org/citations/26791245 | http://purl.uniprot.org/core/author | "Norbury C."xsd:string |
| http://purl.uniprot.org/citations/26791245 | http://purl.uniprot.org/core/author | "Ni B."xsd:string |
| http://purl.uniprot.org/citations/26791245 | http://purl.uniprot.org/core/author | "Sandhu P."xsd:string |
| http://purl.uniprot.org/citations/26791245 | http://purl.uniprot.org/core/author | "Song J.'"xsd:string |
| http://purl.uniprot.org/citations/26791245 | http://purl.uniprot.org/core/author | "Fino K."xsd:string |
| http://purl.uniprot.org/citations/26791245 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26791245 | http://purl.uniprot.org/core/name | "Open Biol"xsd:string |
| http://purl.uniprot.org/citations/26791245 | http://purl.uniprot.org/core/pages | "150208"xsd:string |
| http://purl.uniprot.org/citations/26791245 | http://purl.uniprot.org/core/title | "C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection."xsd:string |
| http://purl.uniprot.org/citations/26791245 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/26791245 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26791245 |
| http://purl.uniprot.org/citations/26791245 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26791245 |
| http://purl.uniprot.org/uniprot/#_O88594-mappedCitation-26791245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26791245 |
| http://purl.uniprot.org/uniprot/#_P01108-mappedCitation-26791245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26791245 |
| http://purl.uniprot.org/uniprot/#_Q6WDF1-mappedCitation-26791245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26791245 |
| http://purl.uniprot.org/uniprot/#_Q8K3Z5-mappedCitation-26791245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26791245 |