| http://purl.uniprot.org/citations/26799667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26799667 | http://www.w3.org/2000/01/rdf-schema#comment | "TGF-β1 is a major player in chronic liver diseases promoting fibrogenesis and tumorigenesis through various mechanisms. The expression and function of TGF-β2 have not been investigated thoroughly in liver disease to date. In this paper, we provide evidence that TGF-β2 expression correlates with fibrogenesis and liver cancer development.Using quantitative realtime PCR and ELISA, we show that TGF-β2 mRNA expression and secretion increased in murine HSCs and hepatocytes over time in culture and were found in the human-derived HSC cell line LX-2. TGF-β2 stimulation of the LX-2 cells led to upregulation of the TGF-β receptors 1, 2, and 3, whereas TGF-β1 treatment did not alter or decrease their expression. In liver regeneration and fibrosis upon CCl4 challenge, the transient increase of TGF-β2 expression was accompanied by TGF-β1 and collagen expression. In bile duct ligation-induced fibrosis, TGF-β2 upregulation correlated with fibrotic markers and was more prominent than TGF-β1 expression. Accordingly, MDR2-KO mice showed significant TGF-β2 upregulation within 3 to 15 months but minor TGF-β1 expression changes. In 5 of 8 hepatocellular carcinoma (HCC)/hepatoblastoma cell lines, relatively high TGF-β2 expression and secretion were observed, with some cell lines even secreting more TGF-β2 than TGF-β1. TGF-β2 was also upregulated in tumors of TGFα/cMyc and DEN-treated mice. The analysis of publically available microarray data of 13 human HCC collectives revealed considerable upregulation of TGF-β2 as compared to normal liver.Our study demonstrates upregulation of TGF-β2 in liver disease and suggests TGF-β2 as a promising therapeutic target for tackling fibrosis and HCC."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.6967"xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/author | "Thomas M."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/author | "Fabregat I."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/author | "Hess J."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/author | "Angel P."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/author | "Bertran E."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/author | "Meindl-Beinker N.M."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/author | "Janicot M."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/author | "Dooley S."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/author | "Coulouarn C."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/author | "Piiper A."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/author | "Korhonen H."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/author | "Abshagen K."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/author | "Weber S.N."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/author | "Breitkopf-Heinlein K."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/author | "Dediulia T."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/author | "Dropmann A."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/pages | "19499-19518"xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/title | "TGF-beta1 and TGF-beta2 abundance in liver diseases of mice and men."xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/26799667 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26799667 |