| http://purl.uniprot.org/citations/26800871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26800871 | http://www.w3.org/2000/01/rdf-schema#comment | "MHC class I downregulation represents a significant challenge for successful T cell-based immunotherapy. T cell epitopes associated with impaired peptide processing (TEIPP) constitute a novel category of immunogenic Ags that are selectively presented on transporter associated with Ag processing-deficient cells. The TEIPP neoepitopes are CD8 T cell targets, derived from nonmutated self-proteins that might be exploited to prevent immune escape. In this study, the crystal structure of H-2D(b) in complex with the first identified TEIPP Ag (MCLRMTAVM) derived from the Trh4 protein has been determined to 2.25 Å resolution. In contrast to prototypic H-2D(b) peptides, Trh4 takes a noncanonical peptide-binding pattern with extensive sulfur-π interactions that contribute to the overall complex stability. Importantly, the noncanonical methionine at peptide position 5 acts as a main anchor, altering only the conformation of the H-2D(b) residues Y156 and H155 and thereby forming a unique MHC/peptide conformer that is essential for recognition by TEIPP-specific T cells. Substitution of peptide residues p2C and p5M to the conservative α-aminobutyric acid and norleucine, respectively, significantly reduced complex stability, without altering peptide conformation or T cell recognition. In contrast, substitution of p5M to a conventional asparagine abolished recognition by the H-2D(b)/Trh4-specific T cell clone LnB5. We anticipate that the H-2D(b)/Trh4 complex represents the first example, to our knowledge, of a broader repertoire of alternative MHC class I binders."xsd:string |
| http://purl.uniprot.org/citations/26800871 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1502249"xsd:string |
| http://purl.uniprot.org/citations/26800871 | http://purl.uniprot.org/core/author | "Achour A."xsd:string |
| http://purl.uniprot.org/citations/26800871 | http://purl.uniprot.org/core/author | "Sandalova T."xsd:string |
| http://purl.uniprot.org/citations/26800871 | http://purl.uniprot.org/core/author | "Buratto J."xsd:string |
| http://purl.uniprot.org/citations/26800871 | http://purl.uniprot.org/core/author | "Duru A.D."xsd:string |
| http://purl.uniprot.org/citations/26800871 | http://purl.uniprot.org/core/author | "Hafstrand I."xsd:string |
| http://purl.uniprot.org/citations/26800871 | http://purl.uniprot.org/core/author | "Oliveira C.C."xsd:string |
| http://purl.uniprot.org/citations/26800871 | http://purl.uniprot.org/core/author | "van Hall T."xsd:string |
| http://purl.uniprot.org/citations/26800871 | http://purl.uniprot.org/core/author | "Doorduijn E.M."xsd:string |
| http://purl.uniprot.org/citations/26800871 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26800871 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/26800871 | http://purl.uniprot.org/core/pages | "2327-2334"xsd:string |
| http://purl.uniprot.org/citations/26800871 | http://purl.uniprot.org/core/title | "The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer."xsd:string |
| http://purl.uniprot.org/citations/26800871 | http://purl.uniprot.org/core/volume | "196"xsd:string |
| http://purl.uniprot.org/citations/26800871 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26800871 |
| http://purl.uniprot.org/citations/26800871 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26800871 |
| http://purl.uniprot.org/uniprot/#_P01887-mappedCitation-26800871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26800871 |
| http://purl.uniprot.org/uniprot/#_P01899-mappedCitation-26800871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26800871 |
| http://purl.uniprot.org/uniprot/#_Q9D6K9-mappedCitation-26800871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26800871 |
| http://purl.uniprot.org/uniprot/P01887 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26800871 |
| http://purl.uniprot.org/uniprot/P01899 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26800871 |
| http://purl.uniprot.org/uniprot/Q9D6K9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/26800871 |