| http://purl.uniprot.org/citations/26803058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26803058 | http://www.w3.org/2000/01/rdf-schema#comment | "The β2-adrenergic receptor (β2-AR) plays a crucial role in pancreatic ductal adenocarcinoma (PDAC) progression. In this report, we identified poly(rC)-binding protein 2 (PCBP2) as a novel binding partner for β2-AR using immunoprecipitation-mass spectrometry (IP-MS) approach. The association between β2-AR and PCBP2 was verified using reciprocal immunoprecipitation. Importantly, we found significant interaction and co-localization of the two proteins in the presence of β2-AR agonist in Panc-1 and Bxpc3 PDAC cells. β2-AR-induced recruitment of PCBP2 led to augmented protein level of c-myc in PDAC cells, likely as a result of enhanced internal ribosome entry segment (IRES)-mediated translation of c-myc. The activation of β2-AR accelerated cell proliferation and colony formation, while knockdown of PCBP2 or c-myc restrained the effect. Furthermore, overexpression of PCBP2 was observed in human PDAC cell lines and tissue specimens compared to the normal pancreatic ductal epithelial cells and the non-cancerous tissues respectively. Overexpression of β2-AR and PCBP2 was associated with advanced tumor stage and significantly worsened prognosis in patients with PDAC. Our results elucidate a new molecular mechanism by which β2-AR signaling facilitates PDAC progression through triggering PCBP2-dependent c-myc expression."xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.canlet.2016.01.026"xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/author | "He S."xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/author | "Zhou G."xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/author | "Ding X."xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/author | "Cao W."xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/author | "Shen A."xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/author | "Gong C."xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/author | "Fan S."xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/author | "Hua L."xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/author | "Wan C."xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/name | "Cancer Lett"xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/pages | "67-76"xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/title | "beta2-adrenergic receptor signaling promotes pancreatic ductal adenocarcinoma (PDAC) progression through facilitating PCBP2-dependent c-myc expression."xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://purl.uniprot.org/core/volume | "373"xsd:string |
| http://purl.uniprot.org/citations/26803058 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26803058 |
| http://purl.uniprot.org/citations/26803058 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26803058 |