| http://purl.uniprot.org/citations/26804170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26804170 | http://www.w3.org/2000/01/rdf-schema#comment | "Bruton's tyrosine kinase (BTK) is essential for B-cell proliferation/differentiation and it is generally believed that its expression and function are limited to bone marrow-derived cells. Here, we report the identification and characterization of p65BTK, a novel isoform abundantly expressed in colon carcinoma cell lines and tumour tissue samples. p65BTK protein is expressed, through heterogeneous nuclear ribonucleoprotein K (hnRNPK)-dependent and internal ribosome entry site-driven translation, from a transcript containing an alternative first exon in the 5'-untranslated region, and is post-transcriptionally regulated, via hnRNPK, by the mitogen-activated protein kinase (MAPK) pathway. p65BTK is endowed with strong transforming activity that depends on active signal-regulated protein kinases-1/2 (ERK1/2) and its inhibition abolishes RAS transforming activity. Accordingly, p65BTK overexpression in colon cancer tissues correlates with ERK1/2 activation. Moreover, p65BTK inhibition affects growth and survival of colon cancer cells. Our data reveal that BTK, via p65BTK expression, is a novel and powerful oncogene acting downstream of the RAS/MAPK pathway and suggest that its targeting may be a promising therapeutic approach."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2015.504"xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Helin K."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Giordano F."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Ianzano L."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Masiero L."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Leone B.E."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Giovannoni R."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Ferri G.L."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "D'Amato F."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Pisano F."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Grassilli E."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Stanta G."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Lavitrano M."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Cerrito M.G."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Bonin S."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Noli B."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Narloch R."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Bonomo S."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Missaglia C."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Cialdella A."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/author | "Cicirelli V."xsd:string |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26804170 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |