| http://purl.uniprot.org/citations/26808130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26808130 | http://www.w3.org/2000/01/rdf-schema#comment | "Signet-ring cell carcinomas (SRCCs) tend to present at higher stages and thus are generally associated with a worse prognosis. It has been postulated that a deficiency of E-cadherin may be causal in the pathogenesis of SRCC in animal models. In this study, we systemically analyzed the expression of E-cadherin and β-catenin, a key component of the cadherin complex, in 137 consecutive SRCCs of various organ systems to explore the significance of these molecules in the pathogenesis and progression of SRCCs. Seventy-six percent of SRCCs showed loss or reduced E-cadherin expression. Aberrant β-catenin expression, defined as loss of membranous expression and nuclear/cytoplasmic subcellular localization, was observed in 60% of these cases, with the altered β-catenin expression observed most commonly in the breast (93%) and least in the lung (38%) primaries. Further, the aberrant β-catenin was significantly associated with pathologic nodal stage (P=0.002) and clinical stage (P=0.02). Our findings demonstrated that reduced membranous E-cadherin and aberrant β-catenin expression were frequent events in SRCCs of various organs, and that the altered β-catenin expression was significantly associated with advanced disease. The observations further support the importance of these molecules in the pathogenesis of SRCCs, and indicate the fundamental role of the Wnt/β-catenin signaling pathway in the progression of these tumors. Further investigations of the downstream molecules in this cascade may provide potential novel therapeutic targets for this aggressive tumor type."xsd:string |
| http://purl.uniprot.org/citations/26808130 | http://purl.org/dc/terms/identifier | "doi:10.1097/pai.0000000000000317"xsd:string |
| http://purl.uniprot.org/citations/26808130 | http://purl.uniprot.org/core/author | "Wei S."xsd:string |
| http://purl.uniprot.org/citations/26808130 | http://purl.uniprot.org/core/author | "Ren Z."xsd:string |
| http://purl.uniprot.org/citations/26808130 | http://purl.uniprot.org/core/author | "Ma Y.R."xsd:string |
| http://purl.uniprot.org/citations/26808130 | http://purl.uniprot.org/core/author | "Conner M.G."xsd:string |
| http://purl.uniprot.org/citations/26808130 | http://purl.uniprot.org/core/author | "Siegal G.P."xsd:string |
| http://purl.uniprot.org/citations/26808130 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/26808130 | http://purl.uniprot.org/core/name | "Appl Immunohistochem Mol Morphol"xsd:string |
| http://purl.uniprot.org/citations/26808130 | http://purl.uniprot.org/core/pages | "432-438"xsd:string |
| http://purl.uniprot.org/citations/26808130 | http://purl.uniprot.org/core/title | "Reduced E-Cadherin and Aberrant beta-Catenin Expression are Associated With Advanced Disease in Signet-Ring Cell Carcinomas."xsd:string |
| http://purl.uniprot.org/citations/26808130 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/26808130 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26808130 |
| http://purl.uniprot.org/citations/26808130 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26808130 |
| http://purl.uniprot.org/uniprot/#_A0A0E3XJU3-mappedCitation-26808130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26808130 |
| http://purl.uniprot.org/uniprot/#_A0A0U2ZQU7-mappedCitation-26808130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26808130 |
| http://purl.uniprot.org/uniprot/#_A0A140HMB1-mappedCitation-26808130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26808130 |
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| http://purl.uniprot.org/uniprot/#_B4DSW9-mappedCitation-26808130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26808130 |
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| http://purl.uniprot.org/uniprot/#_B4DGU4-mappedCitation-26808130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26808130 |