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http://purl.uniprot.org/citations/26817615http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26817615http://www.w3.org/2000/01/rdf-schema#comment"

Background

Recent researches and relevant patents have been reported to prove the significant value of Caveolin-1 (Cav-1) in cancer diagnosis and treatment.

Objective

Our study aimed to study the role of Cav-1 in gastric cancer progression and investigate the relationship between Cav-1/E-cadherin expression and the clinical status of gastric cancer.

Method

Immunohistochemistry was applied to detect the expression of Cav-1 and E-cadherin in gastric cancer in a tissue microarray. Real-time PCR was used to further detect the mRNA expression of Cav-1 and E-cadherin in tumor-derived and peritumoral tissues and in different gastric cancer cell lines. The expression of E-cadherin was analyzed by Western Blot and the cell migration ability was examined by Transwell migration assays after downregulation of Cav-1 using siRNA.

Results

The staining of Cav-1 and E-cadherin were both strong in all 5 of the normal gastric tissues, while in gastric cancer tissues the staining of Cav-1 and E-cadherin were downregulated (44&33 negative, 21&22weak and 5&15 strong). And their level was correlated with tumor clinical stage, pathological grade, and metastasis status. Moreover, there was a positive correlation between Cav-1 expression and E-cadherin expression in gastric cancer tissues(r = 0.42, P < 0.05). Knockdown of Cav-1 resulted in decreased expression of E-cadherin, cell morphology changes and elevated migration ability of gastric cancer cells.

Conclusion

Decreased expression of Cav-1 and E-cadherin may play an important role in the progression of gastric cancer; Knockdown of Cav-1 may promote EMT of gastric cancer by targeting E-cadherin."xsd:string
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http://purl.uniprot.org/citations/26817615http://purl.uniprot.org/core/author"Cao J."xsd:string
http://purl.uniprot.org/citations/26817615http://purl.uniprot.org/core/author"Jiang T."xsd:string
http://purl.uniprot.org/citations/26817615http://purl.uniprot.org/core/author"Huang K."xsd:string
http://purl.uniprot.org/citations/26817615http://purl.uniprot.org/core/author"Huang C."xsd:string
http://purl.uniprot.org/citations/26817615http://purl.uniprot.org/core/author"Yang G."xsd:string
http://purl.uniprot.org/citations/26817615http://purl.uniprot.org/core/author"Zhang J."xsd:string
http://purl.uniprot.org/citations/26817615http://purl.uniprot.org/core/author"Zhang K."xsd:string
http://purl.uniprot.org/citations/26817615http://purl.uniprot.org/core/author"Wu W."xsd:string
http://purl.uniprot.org/citations/26817615http://purl.uniprot.org/core/author"Xia X."xsd:string
http://purl.uniprot.org/citations/26817615http://purl.uniprot.org/core/author"Qiu Z."xsd:string
http://purl.uniprot.org/citations/26817615http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/26817615http://purl.uniprot.org/core/name"Recent Pat Anticancer Drug Discov"xsd:string
http://purl.uniprot.org/citations/26817615http://purl.uniprot.org/core/pages"236-244"xsd:string
http://purl.uniprot.org/citations/26817615http://purl.uniprot.org/core/title"Decreased Expression of Caveolin-1 and E-Cadherin Correlates with the Clinicopathologic Features of Gastric Cancer and the EMT Process."xsd:string
http://purl.uniprot.org/citations/26817615http://purl.uniprot.org/core/volume"11"xsd:string
http://purl.uniprot.org/citations/26817615http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26817615
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