| http://purl.uniprot.org/citations/26819372 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26819372 | http://www.w3.org/2000/01/rdf-schema#comment | "PDIP46 (SKAR, POLDIP3) was discovered through its interaction with the p50 subunit of human DNA polymerase δ (Pol δ). Its functions in DNA replication are unknown. PDIP46 associates with Pol δ in cell extracts both by immunochemical and protein separation methods, as well as by ChIP analyses. PDIP46 also interacts with PCNA via multiple copies of a novel PCNA binding motif, the APIMs (AlkB homologue-2 PCNA-Interacting Motif). Sites for both p50 and PCNA binding were mapped to the N-terminal region containing the APIMs. Functional assays for the effects of PDIP46 on Pol δ activity on singly primed ssM13 DNA templates revealed that it is a novel and potent activator of Pol δ. The effects of PDIP46 on Pol δ in primer extension, strand displacement and synthesis through simple hairpin structures reveal a mechanism where PDIP46 facilitates Pol δ4 synthesis through regions of secondary structure on complex templates. In addition, evidence was obtained that PDIP46 is also capable of exerting its effects by a direct interaction with Pol δ, independent of PCNA. Mutation of the Pol δ and PCNA binding region resulted in a loss of PDIP46 functions. These studies support the view that PDIP46 is a novel accessory protein for Pol δ that is involved in cellular DNA replication. This raises the possibility that altered expression of PDIP46 or its mutation may affect Pol δ functions in vivo, and thereby be a nexus for altered genomic stability."xsd:string |
| http://purl.uniprot.org/citations/26819372 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.7034"xsd:string |
| http://purl.uniprot.org/citations/26819372 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/26819372 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/26819372 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/26819372 | http://purl.uniprot.org/core/author | "Zheng R."xsd:string |
| http://purl.uniprot.org/citations/26819372 | http://purl.uniprot.org/core/author | "Yue F."xsd:string |
| http://purl.uniprot.org/citations/26819372 | http://purl.uniprot.org/core/author | "Lee M.Y."xsd:string |
| http://purl.uniprot.org/citations/26819372 | http://purl.uniprot.org/core/author | "Rahmeh A.A."xsd:string |
| http://purl.uniprot.org/citations/26819372 | http://purl.uniprot.org/core/author | "Lin S.H."xsd:string |
| http://purl.uniprot.org/citations/26819372 | http://purl.uniprot.org/core/author | "Lee E.Y."xsd:string |
| http://purl.uniprot.org/citations/26819372 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26819372 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/26819372 | http://purl.uniprot.org/core/pages | "6294-6313"xsd:string |
| http://purl.uniprot.org/citations/26819372 | http://purl.uniprot.org/core/title | "PDIP46 (DNA polymerase delta interacting protein 46) is an activating factor for human DNA polymerase delta."xsd:string |
| http://purl.uniprot.org/citations/26819372 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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