| http://purl.uniprot.org/citations/26822082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26822082 | http://www.w3.org/2000/01/rdf-schema#comment | "The HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 haplotype is linked to protection from the development of type 1 diabetes (T1D). However, it is not known at which stages in the natural history of T1D development this haplotype affords protection. We examined a cohort of 3,358 autoantibody-positive relatives of T1D patients in the Pathway to Prevention (PTP) Study of the Type 1 Diabetes TrialNet. The PTP study examines risk factors for T1D and disease progression in relatives. HLA typing revealed that 155 relatives carried this protective haplotype. A comparison with 60 autoantibody-negative relatives suggested protection from autoantibody development. Moreover, the relatives with DRB1*15:01-DQA1*01:02-DQB1*06:02 less frequently expressed autoantibodies associated with higher T1D risk, were less likely to have multiple autoantibodies at baseline, and rarely converted from single to multiple autoantibody positivity on follow-up. These relatives also had lower frequencies of metabolic abnormalities at baseline and exhibited no overall metabolic worsening on follow-up. Ultimately, they had a very low 5-year cumulative incidence of T1D. In conclusion, the protective influence of DRB1*15:01-DQA1*01:02-DQB1*06:02 spans from autoantibody development through all stages of progression, and relatives with this allele only rarely develop T1D."xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.org/dc/terms/identifier | "doi:10.2337/db15-1105"xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/author | "Becker D."xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/author | "Rodriguez H."xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/author | "Harrison L.C."xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/author | "Babu S."xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/author | "Eisenbarth G.S."xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/author | "Pugliese A."xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/author | "Schatz D."xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/author | "Boulware D."xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/author | "DiMeglio L."xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/author | "Greenbaum C."xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/author | "Palmer J.P."xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/author | "Steck A.K."xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/author | "Evans-Molina C."xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/author | "Sosenko J.M."xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/pages | "1109-1119"xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/title | "HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression."xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://purl.uniprot.org/core/volume | "65"xsd:string |
| http://purl.uniprot.org/citations/26822082 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26822082 |
| http://purl.uniprot.org/citations/26822082 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26822082 |