| http://purl.uniprot.org/citations/26823018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26823018 | http://www.w3.org/2000/01/rdf-schema#comment | "Intracellular transport involves the regulation of microtubule motor interactions with cargo, but the underlying mechanisms are not well understood. Septins are membrane- and microtubule-binding proteins that assemble into filamentous, scaffold-like structures. Septins are implicated in microtubule-dependent transport, but their roles are unknown. Here we describe a novel interaction between KIF17, a kinesin 2 family motor, and septin 9 (SEPT9). We show that SEPT9 associates directly with the C-terminal tail of KIF17 and interacts preferentially with the extended cargo-binding conformation of KIF17. In developing rat hippocampal neurons, SEPT9 partially colocalizes and comigrates with KIF17. We show that SEPT9 interacts with the KIF17 tail domain that associates with mLin-10/Mint1, a cargo adaptor/scaffold protein, which underlies the mechanism of KIF17 binding to the NMDA receptor subunit 2B (NR2B). Significantly, SEPT9 interferes with binding of the PDZ1 domain of mLin-10/Mint1 to KIF17 and thereby down-regulates NR2B transport into the dendrites of hippocampal neurons. Measurements of KIF17 motility in live neurons show that SEPT9 does not affect the microtubule-dependent motility of KIF17. These results provide the first evidence of an interaction between septins and a nonmitotic kinesin and suggest that SEPT9 modulates the interactions of KIF17 with membrane cargo."xsd:string |
| http://purl.uniprot.org/citations/26823018 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e15-07-0493"xsd:string |
| http://purl.uniprot.org/citations/26823018 | http://purl.uniprot.org/core/author | "Bai X."xsd:string |
| http://purl.uniprot.org/citations/26823018 | http://purl.uniprot.org/core/author | "Spiliotis E.T."xsd:string |
| http://purl.uniprot.org/citations/26823018 | http://purl.uniprot.org/core/author | "Karasmanis E.P."xsd:string |
| http://purl.uniprot.org/citations/26823018 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26823018 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/26823018 | http://purl.uniprot.org/core/pages | "897-906"xsd:string |
| http://purl.uniprot.org/citations/26823018 | http://purl.uniprot.org/core/title | "Septin 9 interacts with kinesin KIF17 and interferes with the mechanism of NMDA receptor cargo binding and transport."xsd:string |
| http://purl.uniprot.org/citations/26823018 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/26823018 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26823018 |
| http://purl.uniprot.org/citations/26823018 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26823018 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MRS8-mappedCitation-26823018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26823018 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z5W9-mappedCitation-26823018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26823018 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z5A5-mappedCitation-26823018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26823018 |
| http://purl.uniprot.org/uniprot/#_A0A8I6GK23-mappedCitation-26823018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26823018 |
| http://purl.uniprot.org/uniprot/#_A0A8I6GM30-mappedCitation-26823018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26823018 |
| http://purl.uniprot.org/uniprot/#_A6HL10-mappedCitation-26823018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26823018 |
| http://purl.uniprot.org/uniprot/#_A6HL11-mappedCitation-26823018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26823018 |
| http://purl.uniprot.org/uniprot/#_A6HL12-mappedCitation-26823018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26823018 |
| http://purl.uniprot.org/uniprot/#_A6HL13-mappedCitation-26823018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26823018 |
| http://purl.uniprot.org/uniprot/#_A6HL14-mappedCitation-26823018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26823018 |
| http://purl.uniprot.org/uniprot/#_A6ITG8-mappedCitation-26823018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26823018 |
| http://purl.uniprot.org/uniprot/#_B0I1R5-mappedCitation-26823018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26823018 |