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http://purl.uniprot.org/citations/26824492http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26824492http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The pathogenesis of progressive nephropathies involves inflammatory factors. The inhibition of cyclooxygenase-2 (COX-2) can limit renal damage and inflammation. However, the mechanism of up-regulation of COX-2 in nephropathy is poorly defined.

Materials and methods

Here we found that tumor necrosis factor alpha (TNFα) was involved in expression of COX-2 in normal rat kidney (NRK) cell line.

Results

TNFα stimulated COX-2 production in a time-dependent manner in NRK cells by inducing nuclear accumulation of RelB and nuclear factor kappa B2 (NF-κB2) and their association with COX-2 gene promoter. Depletion of IκB-inducing kinase alpha, a positive regulator of activation of p100 processing to active p52, attenuated TNFα-induced COX-2 production. Furthermore, TNFα induced COX-2 production and nuclear import in anti-thymocyte serum (ATS) nephropathy.

Discussion and conclusion

These data suggest that TNFα-RelB/p52 pathway may be involved in the early stages of renal damage, in part by stimulating COX-2 and inflammatory responses."xsd:string
http://purl.uniprot.org/citations/26824492http://purl.org/dc/terms/identifier"doi:10.3109/13813455.2016.1141961"xsd:string
http://purl.uniprot.org/citations/26824492http://purl.uniprot.org/core/author"Chen S."xsd:string
http://purl.uniprot.org/citations/26824492http://purl.uniprot.org/core/author"Chen R."xsd:string
http://purl.uniprot.org/citations/26824492http://purl.uniprot.org/core/author"Qiu J."xsd:string
http://purl.uniprot.org/citations/26824492http://purl.uniprot.org/core/author"Zhou Y."xsd:string
http://purl.uniprot.org/citations/26824492http://purl.uniprot.org/core/author"Song D."xsd:string
http://purl.uniprot.org/citations/26824492http://purl.uniprot.org/core/author"Yuan H."xsd:string
http://purl.uniprot.org/citations/26824492http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/26824492http://purl.uniprot.org/core/name"Arch Physiol Biochem"xsd:string
http://purl.uniprot.org/citations/26824492http://purl.uniprot.org/core/pages"88-93"xsd:string
http://purl.uniprot.org/citations/26824492http://purl.uniprot.org/core/title"TNFalpha up-regulates COX-2 in chronic progressive nephropathy through nuclear accumulation of RelB and NF-kappaB2."xsd:string
http://purl.uniprot.org/citations/26824492http://purl.uniprot.org/core/volume"122"xsd:string
http://purl.uniprot.org/citations/26824492http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26824492
http://purl.uniprot.org/citations/26824492http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26824492
http://purl.uniprot.org/uniprot/#_D3Z9V1-mappedCitation-26824492http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26824492
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http://purl.uniprot.org/uniprot/#_P35355-mappedCitation-26824492http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26824492
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http://purl.uniprot.org/uniprot/#_Q63124-mappedCitation-26824492http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26824492
http://purl.uniprot.org/uniprot/D3Z9V1http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/26824492
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