RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/26825462http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/26825462http://www.w3.org/2000/01/rdf-schema#comment"Meiosis-specific cohesin, required for the linking of the sister chromatids, plays a critical role in various chromosomal events during meiotic prophase I, such as chromosome morphogenesis and dynamics, as well as recombination. Rad61/Wpl1 (Wapl in other organisms) negatively regulates cohesin functions. In this study, we show that meiotic chromosome axes are shortened in the budding yeast rad61/wpl1 mutant, suggesting that Rad61/Wpl1 negatively regulates chromosome axis compaction. Rad61/Wpl1 is required for efficient resolution of telomere clustering during meiosis I, indicating a positive effect of Rad61/Wpl1 on the cohesin function required for telomere dynamics. Additionally, we demonstrate distinct activities of Rad61/Wpl1 during the meiotic recombination, including its effects on the efficient processing of intermediates. Thus, Rad61/Wpl1 both positively and negatively regulates various cohesin-mediated chromosomal processes during meiosis."xsd:string
http://purl.uniprot.org/citations/26825462http://purl.org/dc/terms/identifier"doi:10.1093/nar/gkw034"xsd:string
http://purl.uniprot.org/citations/26825462http://purl.uniprot.org/core/author"Lee M.S."xsd:string
http://purl.uniprot.org/citations/26825462http://purl.uniprot.org/core/author"Kim K.P."xsd:string
http://purl.uniprot.org/citations/26825462http://purl.uniprot.org/core/author"Shinohara M."xsd:string
http://purl.uniprot.org/citations/26825462http://purl.uniprot.org/core/author"Shinohara A."xsd:string
http://purl.uniprot.org/citations/26825462http://purl.uniprot.org/core/author"Challa K."xsd:string
http://purl.uniprot.org/citations/26825462http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/26825462http://purl.uniprot.org/core/name"Nucleic Acids Res"xsd:string
http://purl.uniprot.org/citations/26825462http://purl.uniprot.org/core/pages"3190-3203"xsd:string
http://purl.uniprot.org/citations/26825462http://purl.uniprot.org/core/title"Rad61/Wpl1 (Wapl), a cohesin regulator, controls chromosome compaction during meiosis."xsd:string
http://purl.uniprot.org/citations/26825462http://purl.uniprot.org/core/volume"44"xsd:string
http://purl.uniprot.org/citations/26825462http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/26825462
http://purl.uniprot.org/citations/26825462http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/26825462
http://purl.uniprot.org/uniprot/#_A0A8H8UMT4-mappedCitation-26825462http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26825462
http://purl.uniprot.org/uniprot/#_Q12188-mappedCitation-26825462http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26825462
http://purl.uniprot.org/uniprot/#_Q99359-mappedCitation-26825462http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/26825462
http://purl.uniprot.org/uniprot/A0A8H8UMT4http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/26825462
http://purl.uniprot.org/uniprot/Q99359http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/26825462
http://purl.uniprot.org/uniprot/Q12188http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/26825462