| http://purl.uniprot.org/citations/26826187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26826187 | http://www.w3.org/2000/01/rdf-schema#comment | "Inhibitory proteins, particularly Nogo 66, a highly conserved 66-amino-acid loop of Nogo A (an isoform of RTN4), play key roles in limiting the intrinsic capacity of the central nervous system (CNS) to regenerate after injury. Ligation of surface Nogo receptors (NgRs) and/or leukocyte immunoglobulin-like receptor B2 (LILRB2) and its mouse orthologue the paired immunoglobulin-like receptor B (PIRB) by Nogo 66 transduces inhibitory signals that potently inhibit neurite outgrowth. Here, we show that soluble leukocyte immunoglobulin-like receptor A3 (LILRA3) is a high-affinity receptor for Nogo 66, suggesting that LILRA3 might be a competitive antagonist to these cell surface inhibitory receptors. Consistent with this, LILRA3 significantly reversed Nogo-66-mediated inhibition of neurite outgrowth and promoted synapse formation in primary cortical neurons through regulation of the ERK/MEK pathway. LILRA3 represents a new antagonist to Nogo-66-mediated inhibition of neurite outgrowth in the CNS, a function distinct from its immune-regulatory role in leukocytes. This report is also the first to demonstrate that a member of LILR family normally not expressed in rodents exerts functions on mouse neurons through the highly homologous Nogo 66 ligand."xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.182006"xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://purl.uniprot.org/core/author | "Guillemin G.J."xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://purl.uniprot.org/core/author | "Lim C.K."xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://purl.uniprot.org/core/author | "An H."xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://purl.uniprot.org/core/author | "Lee T."xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://purl.uniprot.org/core/author | "Fath T."xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://purl.uniprot.org/core/author | "Bryant K."xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://purl.uniprot.org/core/author | "Tedla N."xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://purl.uniprot.org/core/author | "Geczy C.L."xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://purl.uniprot.org/core/author | "Klotzsch E."xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://purl.uniprot.org/core/author | "Heng B."xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://purl.uniprot.org/core/author | "Lord M.S."xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://purl.uniprot.org/core/author | "Brettle M."xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26826187 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://purl.uniprot.org/core/pages | "1198-1209"xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://purl.uniprot.org/core/title | "Soluble LILRA3 promotes neurite outgrowth and synapses formation through a high-affinity interaction with Nogo 66."xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://purl.uniprot.org/core/volume | "129"xsd:string |
| http://purl.uniprot.org/citations/26826187 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26826187 |
| http://purl.uniprot.org/citations/26826187 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26826187 |
| http://purl.uniprot.org/uniprot/#_A6XGP7-mappedCitation-26826187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26826187 |
| http://purl.uniprot.org/uniprot/#_B4DZ44-mappedCitation-26826187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26826187 |
| http://purl.uniprot.org/uniprot/#_H2B4M3-mappedCitation-26826187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26826187 |