| http://purl.uniprot.org/citations/26838601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26838601 | http://www.w3.org/2000/01/rdf-schema#comment | "Development of the cerebral cortex requires regulation of proliferation and differentiation of neural stem cells and a diverse range of progenitors. Recent work suggests a role for extracellular matrix (ECM) and the major family of ECM receptors, the integrins. Here we show that enhancing integrin beta-1 signalling, by expressing a constitutively active integrin beta-1 (CA*β1) in the embryonic chick mesencephalon, enhances neurogenesis and increases the number of mitotic cells dividing away from the ventricular surface, analogous to sub-apical progenitors in mouse. Only non-integrin-expressing neighbouring cells (lacking CA*β1) contributed to the increased neurogenesis. Transcriptome analysis reveals upregulation of Wnt7a within the CA*β1 cells and upregulation of the ECM protein Decorin in the neighbouring non-expressing cells. Experiments using inhibitors in explant models and genetic knock-downs in vivo reveal an integrin-Wnt7a-Decorin pathway that promotes proliferation and differentiation of neuroepithelial cells, and identify Decorin as a novel neurogenic factor in the central nervous system."xsd:string |
| http://purl.uniprot.org/citations/26838601 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms10354"xsd:string |
| http://purl.uniprot.org/citations/26838601 | http://purl.uniprot.org/core/author | "Long K."xsd:string |
| http://purl.uniprot.org/citations/26838601 | http://purl.uniprot.org/core/author | "Ffrench-Constant C."xsd:string |
| http://purl.uniprot.org/citations/26838601 | http://purl.uniprot.org/core/author | "Moss L."xsd:string |
| http://purl.uniprot.org/citations/26838601 | http://purl.uniprot.org/core/author | "Boulter L."xsd:string |
| http://purl.uniprot.org/citations/26838601 | http://purl.uniprot.org/core/author | "Laursen L."xsd:string |
| http://purl.uniprot.org/citations/26838601 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26838601 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/26838601 | http://purl.uniprot.org/core/pages | "10354"xsd:string |
| http://purl.uniprot.org/citations/26838601 | http://purl.uniprot.org/core/title | "Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin."xsd:string |
| http://purl.uniprot.org/citations/26838601 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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