| http://purl.uniprot.org/citations/26841696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26841696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26841696 | http://www.w3.org/2000/01/rdf-schema#comment | "Wapl induces cohesin dissociation from DNA throughout the mitotic cell cycle, modulating sister chromatid cohesion and higher-order chromatin structure. Cohesin complexes containing meiosis-specific kleisin subunits govern most aspects of meiotic chromosome function, but whether Wapl regulates these complexes remains unknown. We show that during C. elegans oogenesis WAPL-1 antagonizes binding of cohesin containing COH-3/4 kleisins, but not REC-8, demonstrating that sensitivity to WAPL-1 is dictated by kleisin identity. By restricting the amount of chromosome-associated COH-3/4 cohesin, WAPL-1 controls chromosome structure throughout meiotic prophase. In the absence of REC-8, WAPL-1 inhibits COH-3/4-mediated cohesion, which requires crossover-fated events formed during meiotic recombination. Thus, WAPL-1 promotes functional specialization of meiotic cohesin: WAPL-1-sensitive COH-3/4 complexes modulate higher-order chromosome structure, while WAPL-1-refractory REC-8 complexes provide stable cohesion. Surprisingly, a WAPL-1-independent mechanism removes cohesin before metaphase I. Our studies provide insight into how meiosis-specific cohesin complexes are regulated to ensure formation of euploid gametes."xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.10851"xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.10851"xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/author | "Martinez-Perez E."xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/author | "Martinez-Perez E."xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/author | "Silva N."xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/author | "Silva N."xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/author | "Barroso C."xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/author | "Barroso C."xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/author | "Crawley O."xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/author | "Crawley O."xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/author | "Ferrandiz N."xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/author | "Ferrandiz N."xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/author | "Testori S."xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/author | "Testori S."xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/author | "Castellano-Pozo M."xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/author | "Castellano-Pozo M."xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/author | "Jaso-Tamame A.L."xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/author | "Jaso-Tamame A.L."xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/26841696 | http://purl.uniprot.org/core/name | "Elife"xsd:string |