| http://purl.uniprot.org/citations/26843124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26843124 | http://www.w3.org/2000/01/rdf-schema#comment | "Cancer stem cells (CSCs) contribute to tumour heterogeneity, therapy resistance and metastasis. However, the regulatory mechanisms of cancer cell stemness remain elusive. Here we identify PCNA-associated factor (PAF) as a key molecule that controls cancer cell stemness. PAF is highly expressed in breast cancer cells but not in mammary epithelial cells (MECs). In MECs, ectopic expression of PAF induces anchorage-independent cell growth and breast CSC marker expression. In mouse models, conditional PAF expression induces mammary ductal hyperplasia. Moreover, PAF expression endows MECs with a self-renewing capacity and cell heterogeneity generation via Wnt signalling. Conversely, ablation of endogenous PAF induces the loss of breast cancer cell stemness. Further cancer drug repurposing approaches reveal that NVP-AUY922 downregulates PAF and decreases breast cancer cell stemness. Our results unveil an unsuspected role of the PAF-Wnt signalling axis in modulating cell plasticity, which is required for the maintenance of breast cancer cell stemness."xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms10633"xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://purl.uniprot.org/core/author | "Schneider A."xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://purl.uniprot.org/core/author | "Park B.J."xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://purl.uniprot.org/core/author | "Park J.I."xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://purl.uniprot.org/core/author | "Lin S.H."xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://purl.uniprot.org/core/author | "Jung Y.S."xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://purl.uniprot.org/core/author | "Jun S."xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://purl.uniprot.org/core/author | "Keyomarsi K."xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://purl.uniprot.org/core/author | "Sun Oh Y."xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26843124 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://purl.uniprot.org/core/pages | "10633"xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://purl.uniprot.org/core/title | "PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness."xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/26843124 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26843124 |
| http://purl.uniprot.org/citations/26843124 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26843124 |
| http://purl.uniprot.org/uniprot/#_Q15004-mappedCitation-26843124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26843124 |
| http://purl.uniprot.org/uniprot/#_G9G6C4-mappedCitation-26843124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26843124 |
| http://purl.uniprot.org/uniprot/#_G9G6D7-mappedCitation-26843124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26843124 |