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| http://purl.uniprot.org/citations/26843327 | http://www.w3.org/2000/01/rdf-schema#comment | "Yin Yang 1 (YY1) is a zinc finger protein that functions as a transcriptional activator or repressor and participates in multiple biological processes, including development and tumorigenesis. To investigate the role of YY1 in developing T cells, we used mouse models that depleted YY1 at two distinct stages of thymocyte development. When YY1 was depleted in CD4(-)CD8(-) double-negative thymocytes, development to the CD4(+)CD8(+) double-positive stage was impaired, due to increased apoptosis that prevented expansion of post-β-selection thymocytes. When YY1 was depleted in double-positive thymocytes, they underwent increased cell-autonomous apoptosis in vitro and displayed a shorter lifespan in vivo, as judged by their ability to undergo secondary Vα-to-Jα recombination. Mechanistically, we found that the increased apoptosis in YY1-deficient thymocytes was attributed to overexpression of p53, because concurrent loss of p53 completely rescued the developmental defects of YY1-deficient thymocytes. These results indicated that YY1 functions as a critical regulator of thymocyte survival and that it does so by suppressing the expression of p53."xsd:string |
| http://purl.uniprot.org/citations/26843327 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1501916"xsd:string |
| http://purl.uniprot.org/citations/26843327 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/26843327 | http://purl.uniprot.org/core/author | "Krangel M.S."xsd:string |
| http://purl.uniprot.org/citations/26843327 | http://purl.uniprot.org/core/author | "Sant'Angelo D.B."xsd:string |
| http://purl.uniprot.org/citations/26843327 | http://purl.uniprot.org/core/author | "Foreman D.P."xsd:string |
| http://purl.uniprot.org/citations/26843327 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26843327 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/26843327 | http://purl.uniprot.org/core/pages | "2572-2582"xsd:string |
| http://purl.uniprot.org/citations/26843327 | http://purl.uniprot.org/core/title | "Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53."xsd:string |
| http://purl.uniprot.org/citations/26843327 | http://purl.uniprot.org/core/volume | "196"xsd:string |
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