| http://purl.uniprot.org/citations/26851216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26851216 | http://www.w3.org/2000/01/rdf-schema#comment | "Follicular CD4(+) Th (Tfh) cells provide B cell help in germinal center reactions that support class switching, somatic hypermutation, and the generation of high-affinity Abs. In this article, we show that deficiency in NFAT1 and NFAT2 in CD4(+) T cells leads to impaired germinal center reactions upon viral infection because of reduced Tfh cell differentiation and defective expression of proteins involved in T/B interactions and B cell help, including ICOS, PD-1, and SLAM family receptors. Genome-wide chromatin immunoprecipitation data suggest that NFAT proteins likely directly participate in regulation of genes important for Tfh cell differentiation and function. NFAT proteins are important TCR and Ca(2+)-dependent regulators of T cell biology, and in this article we demonstrate a major positive role of NFAT family members in Tfh differentiation."xsd:string |
| http://purl.uniprot.org/citations/26851216 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1501841"xsd:string |
| http://purl.uniprot.org/citations/26851216 | http://purl.uniprot.org/core/author | "Rao A."xsd:string |
| http://purl.uniprot.org/citations/26851216 | http://purl.uniprot.org/core/author | "Crotty S."xsd:string |
| http://purl.uniprot.org/citations/26851216 | http://purl.uniprot.org/core/author | "Martinez G.J."xsd:string |
| http://purl.uniprot.org/citations/26851216 | http://purl.uniprot.org/core/author | "Hu J.K."xsd:string |
| http://purl.uniprot.org/citations/26851216 | http://purl.uniprot.org/core/author | "Pereira R.M."xsd:string |
| http://purl.uniprot.org/citations/26851216 | http://purl.uniprot.org/core/author | "Crampton J.S."xsd:string |
| http://purl.uniprot.org/citations/26851216 | http://purl.uniprot.org/core/author | "Togher S."xsd:string |
| http://purl.uniprot.org/citations/26851216 | http://purl.uniprot.org/core/author | "Bild N."xsd:string |
| http://purl.uniprot.org/citations/26851216 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26851216 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/26851216 | http://purl.uniprot.org/core/pages | "2015-2019"xsd:string |
| http://purl.uniprot.org/citations/26851216 | http://purl.uniprot.org/core/title | "Cutting Edge: NFAT Transcription Factors Promote the Generation of Follicular Helper T Cells in Response to Acute Viral Infection."xsd:string |
| http://purl.uniprot.org/citations/26851216 | http://purl.uniprot.org/core/volume | "196"xsd:string |
| http://purl.uniprot.org/citations/26851216 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26851216 |
| http://purl.uniprot.org/citations/26851216 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26851216 |
| http://purl.uniprot.org/uniprot/#_A2AQC8-mappedCitation-26851216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26851216 |
| http://purl.uniprot.org/uniprot/#_B5B2N2-mappedCitation-26851216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26851216 |
| http://purl.uniprot.org/uniprot/#_B5B2N4-mappedCitation-26851216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26851216 |
| http://purl.uniprot.org/uniprot/#_B5B2N5-mappedCitation-26851216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26851216 |
| http://purl.uniprot.org/uniprot/#_B5B2N7-mappedCitation-26851216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26851216 |
| http://purl.uniprot.org/uniprot/#_B5B2P6-mappedCitation-26851216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26851216 |
| http://purl.uniprot.org/uniprot/#_B5B2P7-mappedCitation-26851216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26851216 |