| http://purl.uniprot.org/citations/26854227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26854227 | http://www.w3.org/2000/01/rdf-schema#comment | "Regeneration of skeletal muscle requires the continued presence of quiescent muscle stem cells (satellite cells), which become activated in response to injury. Here, we report that whole-body protein arginine methyltransferase PRMT7(-/-) adult mice and mice conditionally lacking PRMT7 in satellite cells using Pax7-CreERT2 both display a significant reduction in satellite cell function, leading to defects in regenerative capacity upon muscle injury. We show that PRMT7 is preferentially expressed in activated satellite cells and, interestingly, PRMT7-deficient satellite cells undergo cell-cycle arrest and premature cellular senescence. These defects underlie poor satellite cell stem cell capacity to regenerate muscle and self-renew after injury. PRMT7-deficient satellite cells express elevated levels of the CDK inhibitor p21CIP1 and low levels of its repressor, DNMT3b. Restoration of DNMT3b in PRMT7-deficient cells rescues PRMT7-mediated senescence. Our findings define PRMT7 as a regulator of the DNMT3b/p21 axis required to maintain muscle stem cell regenerative capacity."xsd:string |
| http://purl.uniprot.org/citations/26854227 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.01.022"xsd:string |
| http://purl.uniprot.org/citations/26854227 | http://purl.uniprot.org/core/author | "Chen T."xsd:string |
| http://purl.uniprot.org/citations/26854227 | http://purl.uniprot.org/core/author | "Richard S."xsd:string |
| http://purl.uniprot.org/citations/26854227 | http://purl.uniprot.org/core/author | "Vogel G."xsd:string |
| http://purl.uniprot.org/citations/26854227 | http://purl.uniprot.org/core/author | "Crist C."xsd:string |
| http://purl.uniprot.org/citations/26854227 | http://purl.uniprot.org/core/author | "Blanc R.S."xsd:string |
| http://purl.uniprot.org/citations/26854227 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26854227 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/26854227 | http://purl.uniprot.org/core/pages | "1528-1539"xsd:string |
| http://purl.uniprot.org/citations/26854227 | http://purl.uniprot.org/core/title | "PRMT7 Preserves Satellite Cell Regenerative Capacity."xsd:string |
| http://purl.uniprot.org/citations/26854227 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/26854227 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26854227 |
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| http://purl.uniprot.org/uniprot/#_D3Z1C9-mappedCitation-26854227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26854227 |
| http://purl.uniprot.org/uniprot/#_D3Z1D0-mappedCitation-26854227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26854227 |
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| http://purl.uniprot.org/uniprot/#_A0A140LJF4-mappedCitation-26854227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26854227 |
| http://purl.uniprot.org/uniprot/#_A0A140LJG1-mappedCitation-26854227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26854227 |