| http://purl.uniprot.org/citations/26854861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26854861 | http://www.w3.org/2000/01/rdf-schema#comment | "Myocardin-related transcription factor-A (MRTF-A) can transduce both biomechanical and humoral signals, which can positively modulate cardiac damage induced by acute myocardial infarction. However, the molecular mechanism that underlies the contribution that MRTF-A provides to the myocardium is not completely understood. The objective of this study was to investigate the effects of MRTF-A on myocardium apoptosis and its mechanisms. Our experiment results showed that MRTF-A expression increased and Bcl-2 expression reduced during myocardial ischemia-reperfusion in rat. Meanwhile, primary cardiomyocytes were pretreated with wild-type MRTF-A or siRNA of MRTF-A before exposure to hypoxia. We found that overexpression of MRTF-A in myocardial cells inhibited apoptosis and the release of cytochrome c. MRTF-A enhanced Bcl-2, which contributes to MRTF-A interaction with Bcl-2 in the nuclei of cardiomyocytes. MRTF-A upregulation expression of Bcl-2 in cardiomyocytes induced by hypoxia was inhibited by PD98059, an ERK1/2 inhibitor. In conclusions, MRTF-A improved myocardial cell survival in a cardiomyocyte model of hypoxia-induced injury; this effect was correlated with the upregulation of anti-apoptotic gene Bcl-2 through the activation of ERK1/2."xsd:string |
| http://purl.uniprot.org/citations/26854861 | http://purl.org/dc/terms/identifier | "doi:10.1139/cjpp-2014-0461"xsd:string |
| http://purl.uniprot.org/citations/26854861 | http://purl.uniprot.org/core/author | "Jiang J."xsd:string |
| http://purl.uniprot.org/citations/26854861 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/26854861 | http://purl.uniprot.org/core/author | "Zhong Z."xsd:string |
| http://purl.uniprot.org/citations/26854861 | http://purl.uniprot.org/core/author | "Wu X.D."xsd:string |
| http://purl.uniprot.org/citations/26854861 | http://purl.uniprot.org/core/author | "Hu J.Q."xsd:string |
| http://purl.uniprot.org/citations/26854861 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26854861 | http://purl.uniprot.org/core/name | "Can J Physiol Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/26854861 | http://purl.uniprot.org/core/pages | "379-387"xsd:string |
| http://purl.uniprot.org/citations/26854861 | http://purl.uniprot.org/core/title | "Anti-apoptotic effects of myocardin-related transcription factor-A on rat cardiomyocytes following hypoxia-induced injury."xsd:string |
| http://purl.uniprot.org/citations/26854861 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/26854861 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26854861 |
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